Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis
文献类型：期刊论文
| 作者 | H. W. Li ; H. S. Zhong ; K. Xu ; K. Yang ; J. Liu ; B. C. Zhang ; F. Zheng ; Y. H. Xia ; L. L. Tan ; D. O. Hong |
| 刊名 | Journal of Endovascular Therapy
 |
| 出版日期 | 2011 |
| 卷号 | 18期号:3页码:407-415 |
| 关键词 | bioabsorbable stent balloon-expandable stent sirolimus-eluting stent neointimal hyperplasia restenosis porcine coronary-arteries metal stents bare-metal implantation paclitaxel safety registry |
| ISSN号 | 1526-6028 |
| 中文摘要 | Purpose: To determine the efficacy of sirolimus-eluting bioabsorbable magnesium alloy stents (SEBMAS) in restenosis prevention. Methods: A balloon-expandable bioabsorbable magnesium alloy stent (BMAS) was created and coated with biodegradable poly(lactic acid-co-trimethylene carbonate) that contained the antiproliferative drug sirolimus (140 +/- 40 mu g/cm(2)). Both the uncoated BMAS and the coated SEBMAS were deployed 2 cm apart in balloon-injured infrarenal abdominal aortas of 20 New Zealand white rabbits. The stented aortic segments were removed at 30, 60, 90, and 120 days (5 rabbits per interval) after implantation. The average stent strut sectional area of each group was measured to evaluate the degree of magnesium corrosion and to forecast the biodegradation time profile of the magnesium stent. Histology and histopathology of the sectioned stented aortic segments were performed to evaluate neointima formation, endothelialization, and inflammation. Results: The SEBMAS degraded gradually after being implanted into the rabbit aorta, and total biocorrosion occurred after similar to 120 days. In all groups, the lumen area was significantly greater, but the neointimal area was significantly smaller in SEBMAS segments compared with the uncoated BMAS segments (p<0.05) at all time points. There was no significant difference in the injury or inflammation scores between the groups. Endothelialization was delayed at 30 days in the SEBMAS segments vs. the uncoated BMAS segments. Conclusion: SEBMAS further reduces intimal hyperplasia and improves the lumen area when compared to uncoated BMAS; however, it delays vascular healing and endothelialization. J Endovasc Ther. 2011; 18: 407-415 |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://210.72.142.130/handle/321006/30466]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | H. W. Li,H. S. Zhong,K. Xu,et al. Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis[J]. Journal of Endovascular Therapy,2011,18(3):407-415. |
| APA | H. W. Li.,H. S. Zhong.,K. Xu.,K. Yang.,J. Liu.,...&D. O. Hong.(2011).Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis.Journal of Endovascular Therapy,18(3),407-415. |
| MLA | H. W. Li,et al."Enhanced Efficacy of Sirolimus-Eluting Bioabsorbable Magnesium Alloy Stents in the Prevention of Restenosis".Journal of Endovascular Therapy 18.3(2011):407-415. |
入库方式： OAI收割
来源：金属研究所
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