Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats
文献类型：期刊论文
| 作者 | W. L. Yang ; Y. Zhang ; J. H. Yang ; L. L. Tan ; K. Yang |
| 刊名 | Journal of Biomedical Materials Research Part A
 |
| 出版日期 | 2011 |
| 卷号 | 99A期号:3页码:386-394 |
| 关键词 | pure magnesium implant osteoporosis BMD diabetic rat in-vivo corrosion to-ultratrace elements dietary magnesium multielement determination bone mass calcium osteoporosis alloys phosphorus deficiency |
| ISSN号 | 1549-3296 |
| 中文摘要 | Pure magnesium (Mg) was implanted intramedullary into the femur of streptozotocin (STZ)-induced diabetic rats to investigate its effect on bone growth after 6 weeks degradation. The experimental results showed that the femoral BMD in diabetic rats was significantly lower than that in controls (p < 0.01) but restored notably by Mg implantation. The contents of calcium (Ca), phosphorus (P), Mg, zinc (Zn), potassium (K), strontium (Sr), and sulfur (S) in bone of diabetic group were significantly lower than those in controls but remarkably increased with implantation of Mg. The residual weight calculation showed that 29.41% of Mg was degraded in vivo. The energy dispersive X-ray spectroscopy (EDS) analysis showed that the reaction layer on the surface of the Mg implant mainly consisted of C, Ca, O, P, and Mg. Besides, serum Mg level was significantly decreased in diabetic group compared with the control group but increased by Mg treatment. Also, there were no significant differences in body weight and blood glucose, as well as blood glycosylated hemoglobin (HbAIc%), serum Ca, alanine aminitransperase (ALT), aspartate aminotransferase (AST), uric acid (UA), nonesterified fatty acid (NEFA), cholinesterase (CHE), and creatinine (CR) levels between diabetic and Mg-implanted rats. The study indicated that Mg implant had no obvious toxicity in STZ-induced diabetic rats and may act as a potential agent to treat osteoporosis. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A: 386-394, 2011. |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/30833]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | W. L. Yang,Y. Zhang,J. H. Yang,et al. Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats[J]. Journal of Biomedical Materials Research Part A,2011,99A(3):386-394. |
| APA | W. L. Yang,Y. Zhang,J. H. Yang,L. L. Tan,&K. Yang.(2011).Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats.Journal of Biomedical Materials Research Part A,99A(3),386-394. |
| MLA | W. L. Yang,et al."Potential antiosteoporosis effect of biodegradable magnesium implanted in STZ-induced diabetic rats".Journal of Biomedical Materials Research Part A 99A.3(2011):386-394. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。