In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy
文献类型：期刊论文
| 作者 | L. P. Xu ; F. Pan ; G. N. Yu ; L. Yang ; E. L. Zhang ; K. Yang |
| 刊名 | Biomaterials
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:8页码:1512-1523 |
| 关键词 | Magnesium Calcium phosphate coating Bioactivity Biocompatility Bone in vitro rest bone implant application simulated body-fluid corrosion properties biomedical applications osteoblast adhesion mg zinc hydroxyapatite titanium ti |
| ISSN号 | 0142-9612 |
| 中文摘要 | Magnesium has shown potential application as a bio-absorbable biomaterial, Such as for bone screws and plates. In order to improve the Surface bioactivity. a calcium phosphate was coated oil a magnesium alloy by a phosphating process (Ca-P coating). The Surface characterization showed that a porous and netlike CaGPO(4)center dot 2H(2)O layer with small amounts of Mg(21) and Zn(21) was formed oil the surface of the Mg alloy. Cells L929 showed significantly good adherence and significantly high growth rate and proliferation characteristics oil the Ca-P coated magnesium alloy (p < 0.05) in in-vitro cell experiments, demonstrating that the Surface cytocompatibility of magnesium was significantly improved by the Ca-P coating. In vivo implantations of the Ca-P coated and the naked alloy rods were carried Out to investigate the bone response at the early stage. Both routine pathological examination and immunohistochemical analysis demonstrated that the Ca-P coating provided magnesium with a significantly good Surface bioactivity (p < 0.05) and promoted early bone growth at the implant/bone interface. It Was suggested that the Ca-P coating might be all effective method to improve the surface bioactivity of magnesium alloy. (C) 2008 Elsevier Ltd. All rights reserved. |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://210.72.142.130/handle/321006/32459]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | L. P. Xu,F. Pan,G. N. Yu,et al. In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy[J]. Biomaterials,2009,30(8):1512-1523. |
| APA | L. P. Xu,F. Pan,G. N. Yu,L. Yang,E. L. Zhang,&K. Yang.(2009).In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy.Biomaterials,30(8),1512-1523. |
| MLA | L. P. Xu,et al."In vitro and in vivo evaluation of the surface bioactivity of a calcium phosphate coated magnesium alloy".Biomaterials 30.8(2009):1512-1523. |
入库方式： OAI收割
来源：金属研究所
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