In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation
文献类型：期刊论文
| 作者 | E. L. Zhang ; L. P. Xu ; G. N. Yu ; F. Pan ; K. Yang |
| 刊名 | Journal of Biomedical Materials Research Part A
 |
| 出版日期 | 2009 |
| 卷号 | 90A期号:3页码:882-893 |
| 关键词 | magnesium alloy bone healing in vivo test degradation osteoconduction commercially pure titanium corrosion behavior stainless-steel hanks solution mg interface surface vitro goat |
| ISSN号 | 1549-3296 |
| 中文摘要 | In vivo degradation of magnesium alloy implant, the bone response to the magnesium, and the effect of the degradation of magnesium on the blood composition and organs were investigated by using light microscopy and scanning electronic microscopy with energy dispersive spectrum. Magnesium alloy showed different degradation rates in the marrow channel and the cortical bone. More degradation of magnesium implant was observed in the marrow channel than in the cortical bone. New bone tissue formed around the magnesium implants after 6 weeks implantation but no fibrous capsule was found. There existed two distinct layers separating the new bone tissue from the magnesium implant. On the magnesium implant side, crystalline magnesium calcium phosphate formed oil the surface of the implant due to the reaction between the implant and blood or body fluid. On the new bone tissue side was a 10-30-mu m membrane comprising two distinct layers with many fibroblasts in the layer close to the new bone tissue. The new bone was in tight contact with the implant through the membrane and phosphate layer due to the good osteoconductivity of the phosphate layer. After 10 and 26 weeks postimplantation, more new bone tissues as well as the membrane were found around the implant. However, no apparent increase in the thickness of the membrane was observed with the increasing of the implantation duration. Blood examination has shown that the degradation of the magnesium implant caused little change to blood composition but no disorder to liver or kidneys. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 882-893, 2009 |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://210.72.142.130/handle/321006/32528]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | E. L. Zhang,L. P. Xu,G. N. Yu,et al. In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation[J]. Journal of Biomedical Materials Research Part A,2009,90A(3):882-893. |
| APA | E. L. Zhang,L. P. Xu,G. N. Yu,F. Pan,&K. Yang.(2009).In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation.Journal of Biomedical Materials Research Part A,90A(3),882-893. |
| MLA | E. L. Zhang,et al."In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation".Journal of Biomedical Materials Research Part A 90A.3(2009):882-893. |
入库方式： OAI收割
来源：金属研究所
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