Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation
文献类型：期刊论文
| 作者 | E. L. Zhang ; C. M. Zou |
| 刊名 | Acta Biomaterialia
 |
| 出版日期 | 2009 |
| 卷号 | 5期号:5页码:1732-1741 |
| 关键词 | Silicon Hydroxyapatite Porous titanium Coating Bioactivity calcium-phosphate mechanical-properties thin-films bone implants coatings ti replacement porosity ingrowth |
| ISSN号 | 1742-7061 |
| 中文摘要 | Porous titanium with a pore size of 150-600 mu m and a porosity of 67% was prepared by fiber sintering. The porous titanium had a complete three-dimensional (3D) interconnected structure and a high yield strength of 100 MPa. Si-substituted hydroxyapatite (Si-HA) was coated on the surface by a biomimetic process to improve the surface bioactivity. X-ray diffraction results showed that Si-HA coating was not well crystallized. New bone tissue was found in the uncoated porous titanium after 2 weeks of implantation and a significant increase (p < 0.05) in the bone ingrowth rate (BIR) was found after 4 weeks of implantation, indicating the good osteoconductivity of the porous structure. The HA-coated and Si-HA-coated porous titanium exhibited a significantly higher BIR than the uncoated titanium at all intervals, highlighting the better surface bioactivity and osteoconductivity of the HA- and Si-HA coatings. Also, the Si-HA-coated porous titanium demonstrated a significantly higher BIR than the HA-coated porous titanium, showing that silicon plays an active role in the surface bioactivity. For Si-HA-coated porous titanium, up to 90% pore area was covered by new bone tissue after 4 weeks of implantation in cortical bone. In the bone marrow cavity, the pore spaces were filled with bone marrow, displaying that the interconnected pore structure could provide a channel for body fluid. It was concluded that both the 3D interconnected pore structure and the Si-HA coating contributed to the high BIR. (c) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| 原文出处 | |
| 公开日期 | 2012-04-13 |
| 源URL | [http://210.72.142.130/handle/321006/32530]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | E. L. Zhang,C. M. Zou. Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation[J]. Acta Biomaterialia,2009,5(5):1732-1741. |
| APA | E. L. Zhang,&C. M. Zou.(2009).Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation.Acta Biomaterialia,5(5),1732-1741. |
| MLA | E. L. Zhang,et al."Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation".Acta Biomaterialia 5.5(2009):1732-1741. |
入库方式： OAI收割
来源：金属研究所
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