DNA damage of germ cell of rat induced by nitrotoluene chemicals
文献类型：SCI/SSCI论文
| 作者 | Li Y.; Li Y. |
| 发表日期 | 2005 |
| 关键词 | nitrotoluenes sertoli/germ cell cocultures SCGE genotoxicity metabolites |
| 英文摘要 | 2,4-dinitrotoluene(2,4-DNT) 9 2 6-dinitrotoluene(2,6-DNT) and 4-nitrotoluene(4-NT) are typical pollutants in the Songhua River of Northeast China. Sertoli/germ cell cocultures and single cell gel electrophoresis(SCGE) are applied to investigate whether they have genotoxicity on DNA damage of germ cell of Kunming male rat. The results showed that all three nitrotoluene compounds tested could induce DNA single-strand breaks of the germ cell. A significant relationship is found between logarithm dose and the degree of DNA damage, which implies that 2,4-DNT, 2,6-DNT and 4-NT have genotoxicity and can induce the germ cell DNA strand to break in vitro. |
| 出处 | Journal of Environmental Sciences-China |
| 卷 | 17 |
| 期 | 1 |
| 页 | 84-90 |
| 收录类别 | SCI |
| 语种 | 英语 |
| ISSN号 | 1001-0742 |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/23592]  |
| 专题 | 地理科学与资源研究所_历年回溯文献 |
| 推荐引用方式 GB/T 7714 | Li Y.,Li Y.. DNA damage of germ cell of rat induced by nitrotoluene chemicals. 2005. |
入库方式： OAI收割
来源：地理科学与资源研究所
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