Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers
文献类型：期刊论文
| 作者 | Hong YL ; Chen XS ; Jing XB ; Fan HS ; Gu ZW ; Zhang XD |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:9页码:1501-1510 |
| 关键词 | SOL-GEL GLASSES HEMOSTATIC ACTIVITY RELEASE SCAFFOLDS MECHANISM MATRICES SYSTEM |
| ISSN号 | 1616-301x |
| 通讯作者 | hong yl |
| 中文摘要 | ultrathin mesoporous bioactive glass hollow fibers (mbghfs) fabricated using an electrospinning technique and combined with a phase-separaiion-induced agent, poly(ethylene oxide) (peo), are described. the rapid solvent evaporation during electrospinning and the peo-induced phase separation process demonstrated play vital roles in the formation of ultrathin bioactive glass fibers with hollow cores and mesoporous walls. immersing the mbghfs in simulated body fluid rapidly results in the development of a layer of enamel-like apatite mesocrystals at the fiber surfaces and apatite nanocrystals inside the hollow cores. drug loading and release experiments indicate that the drug loading capacity and drug release behavior of the mbghfs strongly depends on the fiber length. mbghfs with fiber length >50 mu m can become excellent carriers for drug delivery. the shortening of the fiber length reduces drug loading amounts and accelerates drug release. the mbghfs reported here with sophisticated structure, high bioactivity, and good drug delivery capability can be a promising scaffold for hard tissue repair and wound healing when organized into 3d macroporous membranes. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000277806000019 |
| 公开日期 | 2012-06-06 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43715]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hong YL,Chen XS,Jing XB,et al. Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers[J]. advanced functional materials,2010,20(9):1501-1510. |
| APA | Hong YL,Chen XS,Jing XB,Fan HS,Gu ZW,&Zhang XD.(2010).Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers.advanced functional materials,20(9),1501-1510. |
| MLA | Hong YL,et al."Fabrication and Drug Delivery of Ultrathin Mesoporous Bioactive Glass Hollow Fibers".advanced functional materials 20.9(2010):1501-1510. |
入库方式： OAI收割
来源：长春应用化学研究所
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