Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry
文献类型：期刊论文
| 作者 | Yu Z ; Cui M ; Yan CY ; Song FR ; Liu ZQ ; Liu SY ; Zhang HX |
| 刊名 | journal of mass spectrometry
 |
| 出版日期 | 2010 |
| 卷号 | 45期号:4页码:444-450 |
| 关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY DIMETHYL-BETA-CYCLODEXTRIN INCLUSION COMPLEXES NONCOVALENT COMPLEXES NATURAL-PRODUCTS MS METHOD IDENTIFICATION RECOGNITION CHEMISTRY BINDING |
| ISSN号 | 1076-5174 |
| 通讯作者 | liu sy |
| 中文摘要 | oleanolic acid (oa) and ursolic acid (ua) are isomeric triterpenoid compounds with similar pharmaceutical properties. usually, modern chromatographic and electrophoretic methods are widely utilized to differentiate these two compounds. compared with mass spectrometric (ms) methods, these modern separation methods are both time- and sample-consuming. herein, we present a new method for structural differentiation of oa and ua by fourier transform ion cyclotron resonance mass spectrometry (ft-icr ms) with the association of heptakis-(2,6-di-o-methyl)beta-cyclodextrin (dm-beta-cd). exact ms and tandem ms (ms/ms) data showed that there is no perceptible difference between oa and ua, as well as their beta-cyclodextrin and gamma-cyclodextrin complexes. however, there is a remarkable difference in ms/ms spectra of dm-beta-cd complexes of oa and ua. the peak corresponding to the neutral loss of a formic acid and a water molecule could only be observed in the ms/ms spectrum of the complex of dm-beta-cd: oa. molecular modeling calculations were also employed to further investigate the structural differences of dm-beta-cd: oa and dm-beta-cd : ua complexes. therefore, by employing dm-beta-cd as a reference reagent, oa and ua could be differentiated with purely ms method. copyright (c) 2010 john wiley & sons, ltd. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000277460200012 |
| 公开日期 | 2012-06-06 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43742]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu Z,Cui M,Yan CY,et al. Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry[J]. journal of mass spectrometry,2010,45(4):444-450. |
| APA | Yu Z.,Cui M.,Yan CY.,Song FR.,Liu ZQ.,...&Zhang HX.(2010).Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.journal of mass spectrometry,45(4),444-450. |
| MLA | Yu Z,et al."Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry".journal of mass spectrometry 45.4(2010):444-450. |
入库方式： OAI收割
来源：长春应用化学研究所
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