Recognition and transmembrane delivery of bioconjugated Fe2O3@Au nanoparticles with living cells
文献类型：期刊论文
| 作者 | Sun LL ; Wang JE ; Wang ZX |
| 刊名 | nanoscale
 |
| 出版日期 | 2010 |
| 卷号 | 2期号:2页码:269-276 |
| 关键词 | GROWTH-FACTOR RECEPTOR ARGININE-RICH PEPTIDES IN-VIVO TRACKING GOLD NANOPARTICLES MAGNETIC NANOPARTICLES DNA PROTEOGLYCANS FLUORESCENCE ANTIBODIES COMPLEXES |
| ISSN号 | 2040-3364 |
| 通讯作者 | wang zx |
| 中文摘要 | here, we describe the synthesis of peptide- and/or protein-functionalized fe2o3 core-au shell (fe2o3@au) nanoparticles for imaging and targeting of living cells. when functionalized with the transmembrane peptide rrrrrrrr (r-8), the fe2o3@au nanoparticles (r-8-fe2o3@au) are able to serve as cellular trafficking agents with excellent biocompatibility. the internalization mechanism and delivery efficiency of the r-8-fe2o3@au nanoparticles have been characterized with dark-field microscopy and fluorescence confocal scanning laser microcopy. experimental result suggests that the r-8-fe2o3@au nanoparticles are internalized initially by binding with the membrane-associated proteoglycans on cell surfaces, especially heparan sulfate proteoglycans (hspgs), following an energy-dependent endocytosis process to enter into living cells. after conjugation with the epidermal growth factor receptor antibody (anti-egfr), these nanoparticles can also be used for the recognition of cell membrane antigens to specifically label tumor cells. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000275577100012 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43857]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun LL,Wang JE,Wang ZX. Recognition and transmembrane delivery of bioconjugated Fe2O3@Au nanoparticles with living cells[J]. nanoscale,2010,2(2):269-276. |
| APA | Sun LL,Wang JE,&Wang ZX.(2010).Recognition and transmembrane delivery of bioconjugated Fe2O3@Au nanoparticles with living cells.nanoscale,2(2),269-276. |
| MLA | Sun LL,et al."Recognition and transmembrane delivery of bioconjugated Fe2O3@Au nanoparticles with living cells".nanoscale 2.2(2010):269-276. |
入库方式： OAI收割
来源：长春应用化学研究所
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