DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity
文献类型：期刊论文
| 作者 | Yu HJ ; Zhao CQ ; Chen Y ; Fu ML ; Ren JS ; Qu XG |
| 刊名 | journal of medicinal chemistry
 |
| 出版日期 | 2010 |
| 卷号 | 53期号:1页码:492-498 |
| 关键词 | TELOMERIC G-QUADRUPLEX IN-VIVO G-TETRAPLEX POTASSIUM SOLUTION QUANTITATIVE PCR CYCLIN A(2) K562 CELLS LENGTH SENESCENCE REPEAT |
| ISSN号 | 0022-2623 |
| 通讯作者 | qu xg |
| 中文摘要 | it is important to develop g-quadruplex binding agents that call discriminate between different quadruplexes. recently we reported the first example that a chiral supramolecular complex call selectively stabilize human telomeric g-quadruplex among different g-quadruplex and duplex dna, and the two enantiomers show, different inhibition effect on telomerase activity. here, we report that dna loop sequence can be determinant for this chiral complex g-quadruplex selectivity. adenine in the diagonal loop plays all important role in g-quadruplex hybrid structural transition, thus, it strongly influences the chiral complex induced dna structural transition. the complex's preference for human telonleric dna and its chiral selectivity prompted lis to investigate whether tile two enantiomers, m and p, can show different effects on cancer cells. the 11 enantiomers chiral selectivity hits been demonstrated in cancer cells by telomere [3-galactosidase activity, and up-regulation of cyclin-dependent kinase inhibitors p16 and p21. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000273268300042 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/43987]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu HJ,Zhao CQ,Chen Y,et al. DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity[J]. journal of medicinal chemistry,2010,53(1):492-498. |
| APA | Yu HJ,Zhao CQ,Chen Y,Fu ML,Ren JS,&Qu XG.(2010).DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity.journal of medicinal chemistry,53(1),492-498. |
| MLA | Yu HJ,et al."DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity".journal of medicinal chemistry 53.1(2010):492-498. |
入库方式： OAI收割
来源：长春应用化学研究所
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