Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers
文献类型：期刊论文
| 作者 | Li TH ; Han RY ; Wang MZ ; Liu CB ; Jing XB ; Huang YB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:11页码:1570-1578 |
| 关键词 | MULTIBLOCK COPOLYMERS DELIVERY SYSTEMS POLYMERS GLYCOL) |
| ISSN号 | 1616-5187 |
| 通讯作者 | liu cb |
| 中文摘要 | peg-pla copolymers with dumbbell-and y-shaped structures are prepared. they can self-assemble from nanoparticles to micro-sized fusiform micellar particles in aqueous solution. in particular the micelles formed by the (pla)(2)-peg-(pla)(2) particles show a better drug loading capacity and encapsulation efficiency than those formed by linear mpeg-pla. in vitro studies show that the particles formed by y-shaped copolymers show a particularly quick drug release. the copolymers have good biocompatibility with low cytotoxicity. these unique self-assembled systems thus have many possible biomedical applications, such as a sustained delivery of high-dosed water insoluble drugs, quick effective drugs for trauma, controlled delivery of the oral-administration drugs, and so forth. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000297555500015 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44229]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li TH,Han RY,Wang MZ,et al. Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers[J]. macromolecular bioscience,2011,11(11):1570-1578. |
| APA | Li TH,Han RY,Wang MZ,Liu CB,Jing XB,&Huang YB.(2011).Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers.macromolecular bioscience,11(11),1570-1578. |
| MLA | Li TH,et al."Fusiform Micelles from Nonlinear Poly(ethylene glycol)/Polylactide Copolymers as Biodegradable Drug Carriers".macromolecular bioscience 11.11(2011):1570-1578. |
入库方式： OAI收割
来源：长春应用化学研究所
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