Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin-PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)
文献类型：期刊论文
| 作者 | Chang YL ; Meng XL ; Zhao YL ; Li K ; Zhao B ; Zhu M ; Li YP ; Chen XS ; Wang JY |
| 刊名 | journal of colloid and interface science
 |
| 出版日期 | 2011 |
| 卷号 | 363期号:1页码:403-409 |
| 关键词 | RESONANCE CONTRAST AGENTS DELIVERY TUMOR ACID MICELLES LINKAGE |
| ISSN号 | 0021-9797 |
| 通讯作者 | li yp |
| 中文摘要 | ph-responsive drug release system based on the conjugates of pamam dendrimers-doxorubicin (pamam-dox) and superparamagnetic iron oxide (fe(3)o(4)) nanoparticles (ionps) has been constructed and characterized. the ionps were stabilized by mpeg-g2.5 pamam dendrimers. the anticancer drug dox was conjugated to the dendrimer segments of amino-stabilized ionps using hydrazine as the linker via hydrazone bonds, which is acid cleavable and can be used as an ideal ph-responsive drug release system. the drug release profiles of dox-pamam dendrimer conjugates were studied at ph 5.0 and 7.4. the results showed that the hydrolytic release profile can be obtained only at the condition of lysosomal ph (ph = 5.0), and ionps participated in carrying dox to the tumor by the enhanced permeability and retention (epr) effect. these novel dox-conjugated ionps have the potential to enhance the effect of mri contrast and cancer therapy in the course of delivering anticancer drugs to their target sites. although the dendrimer-dox-coated ionps do not have any targeting ligands attached on their surface, they are potentially useful for cancer diagnosis in vivo. (c) 2011 elsevier inc. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294740400049 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44266]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chang YL,Meng XL,Zhao YL,et al. Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin-PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)[J]. journal of colloid and interface science,2011,363(1):403-409. |
| APA | Chang YL.,Meng XL.,Zhao YL.,Li K.,Zhao B.,...&Wang JY.(2011).Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin-PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs).journal of colloid and interface science,363(1),403-409. |
| MLA | Chang YL,et al."Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin-PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)".journal of colloid and interface science 363.1(2011):403-409. |
入库方式： OAI收割
来源：长春应用化学研究所
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