Preparation of Tetraamino-Phthalocyanine Zinc Loaded Silica Nanoparticles and Its Cytotoxicity Study
文献类型：期刊论文
| 作者 | Zhuang QF ; Wang JE ; Zhu ZJ ; Li F ; Wang ZX |
| 刊名 | chinese journal of analytical chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 39期号:10页码:1567-1571 |
| 关键词 | PHOTODYNAMIC THERAPY CARRIER CANCER |
| ISSN号 | 0253-3820 |
| 通讯作者 | li f |
| 中文摘要 | positive charged silica nanoparticles, entrapping hydrophobic photosensitizer 2,9,16, 23-tetraamino-phthalocyanine zinc (znpc(nh(2))(4)), have been synthesized in the nonpolar core of micelles by hydrolysis of triethoxyvinylsilane (tevs) and 3-aminopropyltriethoxysilane (aptes). the water-soluble, stability, surface morphologies and charge were characterized using transmission electron microscopy (tem), dynamic light scattering (dls) and uv-visible spectrophotometer. the as-prepared nanoparticles are highly monodispersed spheres with uniform diameter (about 20 nm), and stable in aqueous system. its average potential value is 28. 8 +/- 2. 79 mv and exhibits strong absorption peak at 714 nm. in addition, encapsulation of znpc(nh(2))(4), in the silica nanoparticles prevented znpc (nh(2))(4) from leaking and enhanced the anti-photobleaching. the znpc (nh(2))(4) entrapped-nanoparticles (sio(2)@znpc(nh(2))(4)) can efficiently generat singlet oxygen as measured by chemical probe 1,3-diphenylisobenzofuran (dpbf). the toxicity of silica nanoparticles to cells has been investigated by the incubation of the znpc(nh(2))(4), entrapped-nanoparticles and the nanoparticles without znpc(nh(2))(4)(sio(2)-nh(2)) with living cancer cells (hela, u251, pc-12). the experimental result reveals that both sio(2)@znpc(nh(2))(4) and sio(2)-nh(2) particles have no significant toxicity when the concentration of the particles is below 300 mg/l. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000298456000021 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44304]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhuang QF,Wang JE,Zhu ZJ,et al. Preparation of Tetraamino-Phthalocyanine Zinc Loaded Silica Nanoparticles and Its Cytotoxicity Study[J]. chinese journal of analytical chemistry,2011,39(10):1567-1571. |
| APA | Zhuang QF,Wang JE,Zhu ZJ,Li F,&Wang ZX.(2011).Preparation of Tetraamino-Phthalocyanine Zinc Loaded Silica Nanoparticles and Its Cytotoxicity Study.chinese journal of analytical chemistry,39(10),1567-1571. |
| MLA | Zhuang QF,et al."Preparation of Tetraamino-Phthalocyanine Zinc Loaded Silica Nanoparticles and Its Cytotoxicity Study".chinese journal of analytical chemistry 39.10(2011):1567-1571. |
入库方式： OAI收割
来源：长春应用化学研究所
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