Landscape, Flux, Correlation, Resonance, Coherence, Stability, and Key Network Wirings of Stochastic Circadian Oscillation
文献类型：期刊论文
| 作者 | Li CH ; Wang EK ; Wang J |
| 刊名 | biophysical journal
 |
| 出版日期 | 2011 |
| 卷号 | 101期号:6页码:1335-1344 |
| 关键词 | COUPLED CHEMICAL-REACTIONS CELL CYCLE NETWORK GENE-EXPRESSION DISSIPATION COST ENERGY LANDSCAPE INTRINSIC NOISE MOLECULAR NOISE ROBUSTNESS |
| ISSN号 | 0006-3495 |
| 通讯作者 | wang ek |
| 中文摘要 | circadian rhythms with a period of similar to 24 h, are natural timing machines. they are broadly distributed in living organisms, such as neurospora, drosophila, and mammals. the underlying natures of the rhythmic behavior have been explored by experimental and theoretical approaches. however, the global and physical natures of the oscillation under fluctuations are still not very clear. we developed a landscape and flux framework to explore the global stability and robustness of a circadian oscillation system. the potential landscape of the network is uncovered and has a global mexican-hat shape. the height of the mexican-hat provides a quantitative measure to evaluate the robustness and coherence of the oscillation. we found that in nonequilibrium dynamic systems, not only the potential landscape but also the probability flux are important to the dynamics of the system under intrinsic noise. landscape attracts the systems down to the oscillation ring while flux drives the coherent oscillation on the ring. we also investigated the phase coherence and the entropy production rate of the system at different fluctuations and found that dissipations are less and the coherence is higher for larger number of molecules. we also found that the power spectrum of autocorrelation functions show resonance peak at the frequency of coherent oscillations. the peak is less prominent for smaller number of molecules and less barrier height and therefore can be used as another measure of stability of oscillations. as a consequence of nonzero probability flux, we show that the three-point correlations from the time traces show irreversibility, providing a possible way to explore the flux from the observations. furthermore, we explored the escape time from the oscillation ring to outside at different molecular number. we found that when barrier height is higher, escape time is longer and phase coherence of oscillation is higher. finally, we performed the global sensitivity analysis of the underlying parameters to find the key network wirings responsible for the stability of the oscillation system. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000295197300007 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44339]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li CH,Wang EK,Wang J. Landscape, Flux, Correlation, Resonance, Coherence, Stability, and Key Network Wirings of Stochastic Circadian Oscillation[J]. biophysical journal,2011,101(6):1335-1344. |
| APA | Li CH,Wang EK,&Wang J.(2011).Landscape, Flux, Correlation, Resonance, Coherence, Stability, and Key Network Wirings of Stochastic Circadian Oscillation.biophysical journal,101(6),1335-1344. |
| MLA | Li CH,et al."Landscape, Flux, Correlation, Resonance, Coherence, Stability, and Key Network Wirings of Stochastic Circadian Oscillation".biophysical journal 101.6(2011):1335-1344. |
入库方式： OAI收割
来源：长春应用化学研究所
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