Isoliquiritigenin (4,2 ',4 '-trihydroxychalcone): A new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides
文献类型：期刊论文
| 作者 | Yang HM ; Wang JW ; Song FR ; Zhou YH ; Liu SY |
| 刊名 | analytica chimica acta
 |
| 出版日期 | 2011 |
| 卷号 | 701期号:1页码:45-51 |
| 关键词 | IONIC LIQUID MATRICES 2 MASS-SPECTROMETRIC ANALYSIS 5-DIHYDROXYBENZOIC ACID MALDI-MS ANALYSIS TOF MS GLYCANS SAMPLES GLYCOPEPTIDES IONIZATION UPDATE |
| ISSN号 | 0003-2670 |
| 通讯作者 | liu sy |
| 中文摘要 | a novel matrix of isoliquiritigenin (isl), a flavonoid with a chalcone structure (4,2',4'-trihydroxychalcone), was demonstrated to be advantageous in the analysis of neutral oligosaccharides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms). with isl as a matrix, adequate signal for an analyte can be obtained in much lower matrix concentrations and laser intensity compared to commonly used maldi matrices. four different sample preparation methods were tested, and the dried droplet method exhibited the best performance on maldi-tof-ms analysis of oligosaccharides with isl as a matrix. for the analysis of carbohydrates, compared with popular matrices such as 2,5-dihydroxybenzoic acid (dhb) and 2,4,6-trihydroxyacetophenone (thap), isl exhibited outstanding matrix properties as follows: (1) higher homogeneity of crystallization thus allowing automatic data acquisition, (2) better spectral quality in terms of resolution and signal to noise ratio (sn(-1)), (3) better salt tolerance, (4) higher sensitivity, and (5) enough fragmentation yield to use lift-tof/tof ms to get richer structural information. in addition, reliable quantitative analysis of oligosaccharides with a good linearity over two concentration orders (1-100 pmol mu l(-1)) and good reproducibility of the signal intensity (rsd less than 15%) were achieved using this matrix. these results give a new outlook on high-speed analysis of neutral carbohydrates by maldi-tof ms. (c) 2011 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293871900007 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44361]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yang HM,Wang JW,Song FR,et al. Isoliquiritigenin (4,2 ',4 '-trihydroxychalcone): A new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides[J]. analytica chimica acta,2011,701(1):45-51. |
| APA | Yang HM,Wang JW,Song FR,Zhou YH,&Liu SY.(2011).Isoliquiritigenin (4,2 ',4 '-trihydroxychalcone): A new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides.analytica chimica acta,701(1),45-51. |
| MLA | Yang HM,et al."Isoliquiritigenin (4,2 ',4 '-trihydroxychalcone): A new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides".analytica chimica acta 701.1(2011):45-51. |
入库方式： OAI收割
来源：长春应用化学研究所
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