A metabonomic analysis of organ specific response to USPIO administration
文献类型：期刊论文
| 作者 | Feng JH ; Liu HL ; Bhakoo KK ; Lu LH ; Chen Z |
| 刊名 | biomaterials
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:27页码:6558-6569 |
| 关键词 | IRON-OXIDE NANOPARTICLES MICROBIOME MOUSE MODEL SPECTROSCOPY LIVER RATS MRI TISSUE CELLS |
| ISSN号 | 0142-9612 |
| 通讯作者 | feng jh |
| 中文摘要 | as ultrasmall superparamagnetic particles of iron oxides (uspio) have been widely used in clinical medicine as mri contrast agents, hence their potential toxicity and adverse effects following administration have attracted particular attention. in the present study, high resolution magic-angle-spinning (1)h nmr spectroscopy coupled with multivariate statistical analysis was used to directly determine the metabolic consequences of specific-tissues, including kidney, liver and spleen following the intravenous administration of uspio. alterations of renal, hepatic and splenic function were reflected by changes in a number of metabolic pathways including small molecules involved in energy, lipid, glucose, and amino acids metabolism. the toxicological potential and metabolic fate of uspio seems to be linked to their surface chemistry and particle size. hierarchical principal component analysis was used to explore the multidimensional metabolic relationships between various biological matrices such as kidney, liver, spleen, plasma and urine. information on the involvement of uspio in transportation, absorption, biotransformation, biodistribution and secretion was derived from metabolic correlation analysis between different organs and biofluids. such a metabonomic strategy provides methodology for investigating the potential adverse biological effects of similar nanoparticles on the environmental and human health and assessing the drug interventions on the targeted organ. (c) 2011 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293429700022 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44386]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Feng JH,Liu HL,Bhakoo KK,et al. A metabonomic analysis of organ specific response to USPIO administration[J]. biomaterials,2011,32(27):6558-6569. |
| APA | Feng JH,Liu HL,Bhakoo KK,Lu LH,&Chen Z.(2011).A metabonomic analysis of organ specific response to USPIO administration.biomaterials,32(27),6558-6569. |
| MLA | Feng JH,et al."A metabonomic analysis of organ specific response to USPIO administration".biomaterials 32.27(2011):6558-6569. |
入库方式： OAI收割
来源：长春应用化学研究所
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