ECD Technology in Biological Mass Spectrometry
文献类型：期刊论文
| 作者 | Shi L ; Liu SY ; Zubarev RA |
| 刊名 | progress in chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 23期号:8页码:1710-1718 |
| 关键词 | ELECTRON-CAPTURE DISSOCIATION PEPTIDE CATION-RADICALS CHARGED PROTEIN CATIONS GAS-PHASE SITES IONS BOND IDENTIFICATION FRAGMENTATION ENERGETICS |
| ISSN号 | 1005-281x |
| 通讯作者 | liu sy |
| 中文摘要 | electron capture dissociation (ecd) which is believed to be non-ergodic process is a new fragmentation technique used in fourier transformation cyclotron resonance mass spectrometry and is complementary to conventional tandem mass spectrometry techniques. its cleavage preferentially happens not only on n-c(alpha) bond but also on disulfide bonds (s-s) in polypeptides, which are normally stable to vibrational excitation. the labile post-translational modifications and non-covalent bonds often remain intact after backbone bond dissociation. ecd provides more extensive sequence coverage in polypeptides, and at higher electron energies even isoleucine and leucine are distinguishable. the combination of cad and ecd improves protein identification and enables high-throughput de novo sequencing of proteins. an overview of the principle and mechanism of ecd as well as its application in biological mass spectrometry is given. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294191200013 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44394]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Shi L,Liu SY,Zubarev RA. ECD Technology in Biological Mass Spectrometry[J]. progress in chemistry,2011,23(8):1710-1718. |
| APA | Shi L,Liu SY,&Zubarev RA.(2011).ECD Technology in Biological Mass Spectrometry.progress in chemistry,23(8),1710-1718. |
| MLA | Shi L,et al."ECD Technology in Biological Mass Spectrometry".progress in chemistry 23.8(2011):1710-1718. |
入库方式： OAI收割
来源：长春应用化学研究所
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