Core-Shell Structured Up-Conversion Luminescent and Mesoporous NaYF(4):Yb(3+)/Er(3+)@nSiO(2)@mSiO(2) Nanospheres as Carriers for Drug Delivery
文献类型：期刊论文
| 作者 | Kang XJ ; Cheng ZY ; Li CX ; Yang DM ; Shang MM ; Ma PA ; Li GG ; Liu NA ; Lin J |
| 刊名 | journal of physical chemistry c
 |
| 出版日期 | 2011 |
| 卷号 | 115期号:32页码:15801-15811 |
| 关键词 | SHAPE-CONTROLLABLE SYNTHESIS SILICA NANOPARTICLES CONTROLLED-RELEASE SYSTEM FUNCTIONALIZATION HYDROXYAPATITE NANOCOMPOSITE NANOCRYSTALS FLUORESCENCE SPHERES |
| ISSN号 | 1932-7447 |
| 通讯作者 | cheng zy |
| 中文摘要 | core shell structured up-conversion luminescent and mesoporous nayf(4):yb(3+)/er(3+)@nsio(2)@msio(2) nanospheres were prepared by coating mesoporous sio(2) layers with different thicknesses on nayf(4):yb(3+)/ er(3+) nanoparticles via a simple two-step sol-gel process. the obtained sample shows a typical mesoporous structure and well-dispersed spherical morphology with a narrow size distribution. the nanospheres exhibit little cytotoxicity (via mtt assay), and ibuprofen (ibu) was used as a model drug to access the release properties of the system in detail. the amount of ibu adsorbed in mesoporous channels increases with the thickness of the ordered mesoporous silica shell coated on the nayf(4):yb(3+)/er(3+) nanoparticles. the in vitro release study of ibu reveals a release profile in two steps: an initial diffusion-controlled release, followed by a slower release rate. furthermore, upon excitation by a 980 nm near-infrared laser, the nanospheres emit green ((2)h(11/2) and (4)s(3/2) -> (4)i(15/2)) and fed ((4)f(9/2) -> (4)i(15/2)) fluorescence of er(3+) even after the loading of ibu. interestingly, the emission intensity of er(3+) in the bifunctional (mesoporous and luminescence) drug carrier increases` with an increase of the cumulative released amount of the model drug (ibu). thus, the extent of drug release cart be easily identified, tracked, and monitored based on the change of the up-conversion luminescence. these results suggest that the core-shell structured nayf(4):yb(3+)/er(3+)@nsio(2)@msio(2) nanospheres are a promising material for controlled drug release. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44398]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Kang XJ,Cheng ZY,Li CX,et al. Core-Shell Structured Up-Conversion Luminescent and Mesoporous NaYF(4):Yb(3+)/Er(3+)@nSiO(2)@mSiO(2) Nanospheres as Carriers for Drug Delivery[J]. journal of physical chemistry c,2011,115(32):15801-15811. |
| APA | Kang XJ.,Cheng ZY.,Li CX.,Yang DM.,Shang MM.,...&Lin J.(2011).Core-Shell Structured Up-Conversion Luminescent and Mesoporous NaYF(4):Yb(3+)/Er(3+)@nSiO(2)@mSiO(2) Nanospheres as Carriers for Drug Delivery.journal of physical chemistry c,115(32),15801-15811. |
| MLA | Kang XJ,et al."Core-Shell Structured Up-Conversion Luminescent and Mesoporous NaYF(4):Yb(3+)/Er(3+)@nSiO(2)@mSiO(2) Nanospheres as Carriers for Drug Delivery".journal of physical chemistry c 115.32(2011):15801-15811. |
入库方式： OAI收割
来源：长春应用化学研究所
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