Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS
文献类型：期刊论文
| 作者 | Han TJ ; Song FR ; Liu ZY ; Pi ZF ; Liu ZQ ; Liu SY |
| 刊名 | acta chimica sinica
 |
| 出版日期 | 2011 |
| 卷号 | 69期号:15页码:1795-1802 |
| 关键词 | TANDEM-MASS-SPECTROMETRY RADIX-ACONITI PERMEABILITY |
| ISSN号 | 0567-7351 |
| 通讯作者 | han tj |
| 中文摘要 | a uplc/ms method has been established to analyze the diterpenoid alkaloids transportation in the aconitum carmichaeli with the caco-2 cell monolayer. different combination herbs' water extracts including radix glycyrrhizae, rhizoma zingiberis, rhizoma pinelliae or bulbus frltillariae thunbergii have been mixed with the same concentration of the aconitum carmichaeli alkaloids extract solution. the mixing ratio was converted into their medicinal herbs mass of 1 to 1. the results demonstrated that the bioavailability of the diterpenoid alkaloids especially the diester-diterpenoid alkaloids has been decreased by the adding of the radix glycyrrhizae, rhizoma zingiberis or rhizoma pinelliae extracts, which are the most toxicity compounds in the aconitum carmichaeli. however, the bioavailability of the diterpenoid alkaloids in the absorption and efflux has been increased by the adding of the bulbus frltillariae thunbergii extract, respectively. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000294375200011 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44408]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han TJ,Song FR,Liu ZY,et al. Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS[J]. acta chimica sinica,2011,69(15):1795-1802. |
| APA | Han TJ,Song FR,Liu ZY,Pi ZF,Liu ZQ,&Liu SY.(2011).Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS.acta chimica sinica,69(15),1795-1802. |
| MLA | Han TJ,et al."Studies of the Intestinal Transport of the Diterpenoid Alkaloids in the Aconitum carmichaeli Combined with Different Medicinal Herbs in a Caco-2 Cell Culture System with UPLC/MS".acta chimica sinica 69.15(2011):1795-1802. |
入库方式： OAI收割
来源：长春应用化学研究所
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