Stabilization of unstable CGC(+) triplex DNA by single-walled carbon nanotubes under physiological conditions
文献类型：期刊论文
| 作者 | Song YJ ; Feng LY ; Ren JS ; Qu XG |
| 刊名 | nucleic acids research
 |
| 出版日期 | 2011 |
| 卷号 | 39期号:15页码:6835-6843 |
| 关键词 | I-MOTIF DNA NUCLEIC-ACID H-DNA SEQUENCE BINDING PH OLIGOPURINE CHEMISTRY CLEAVAGE BIOLOGY |
| ISSN号 | 0305-1048 |
| 通讯作者 | qu xg |
| 中文摘要 | triplex formation is a promising strategy for realizing artificially controlling of gene expression, reversible assembly of nanomaterials and dna nanomachine and single-walled nanotubes (swnts) have been widely used as gene and drug delivery vector or as 'building blocks' in nano-/microelectronic devices. cgc(+) triplex is not as stable as tat triplex. the poor stability of cgc(+) triplex limits its use in vitro and in vivo. there is no ligand that has been reported to selectively stabilize cgc(+) triplets rather than tat. here, we report that swnts can cause d(ct)center dot d(ag) duplex disproportionation into triplex d(c(+)t)center dot d(ag)center dot d(ct) and single-strand d(ag) under physiological conditions. swnts can reduce the stringency of conditions for cgc(+) triplex formation studied by uv-vis, cd, dna melting, light scattering and atomic force microscopy. further studies indicate that electrostatic interaction is crucial for d(ct)center dot d(ag) repartition into triplex d(c(+)t)center dot d(ag)center dot d(ct). our findings may facilitate utilization of swnts-dna complex in artificially controlling of gene expression, nanomaterials assembly and biosensing. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294555800051 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44420]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song YJ,Feng LY,Ren JS,et al. Stabilization of unstable CGC(+) triplex DNA by single-walled carbon nanotubes under physiological conditions[J]. nucleic acids research,2011,39(15):6835-6843. |
| APA | Song YJ,Feng LY,Ren JS,&Qu XG.(2011).Stabilization of unstable CGC(+) triplex DNA by single-walled carbon nanotubes under physiological conditions.nucleic acids research,39(15),6835-6843. |
| MLA | Song YJ,et al."Stabilization of unstable CGC(+) triplex DNA by single-walled carbon nanotubes under physiological conditions".nucleic acids research 39.15(2011):6835-6843. |
入库方式： OAI收割
来源：长春应用化学研究所
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