Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach
文献类型：期刊论文
| 作者 | Li X ; Zhu DR ; You TY |
| 刊名 | electrophoresis
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:16页码:2139-2147 |
| 关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY RESPONSE-SURFACE METHODOLOGY IONIZATION-MASS-SPECTROMETRY BETA-BLOCKERS ZONE-ELECTROPHORESIS SEPARATION DESIGN PLASMA HYDROCHLORIDE FLUORESCENCE |
| ISSN号 | 0173-0835 |
| 通讯作者 | you ty |
| 中文摘要 | ce coupled with dual electrochemical (ec) and electrochemiluminescence (ecl) detection was optimized for simultaneous analysis of six cardiovascular drugs (alprenolol, propafenone, acebutolol, verapamil, atenolol and metoprolol) via central composite design. following this study, three critical electrophoretic factors governing the ce separation were investigated: tris-h(3)po(4) buffer concentration, buffer ph value and separation voltage. a modified chromatographic response was adopted for evaluating ce separation quality. optimum conditions were achieved using tris-h(3)po(4) buffer 35.6 mm (ph 2.3) separated at 13.9 kv, which was employed experimentally and led to the successful simultaneous separation of the above six drugs. the good agreement of the chromatographic response was observed between predicted data and actual experimental results using these optimized conditions (rsd = 3.75%). the proposed method was validated for linearity, repeatability and sensitivity, and subsequently successfully applied to determine six basic drugs in urine samples. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294180800009 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44421]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li X,Zhu DR,You TY. Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach[J]. electrophoresis,2011,32(16):2139-2147. |
| APA | Li X,Zhu DR,&You TY.(2011).Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach.electrophoresis,32(16),2139-2147. |
| MLA | Li X,et al."Simultaneous analysis of six cardiovascular drugs by capillary electrophoresis coupled with electrochemical and electrochemiluminescence detection, using a chemometrical optimization approach".electrophoresis 32.16(2011):2139-2147. |
入库方式： OAI收割
来源：长春应用化学研究所
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