Determination of nicotine and its metabolite cotinine in urine and cigarette samples by capillary electrophoresis coupled with electrochemiluminescence
文献类型：期刊论文
| 作者 | Sun JY ; Du HW ; You TY |
| 刊名 | electrophoresis
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:16页码:2148-2154 |
| 关键词 | CHROMATOGRAPHY-MASS SPECTROMETRY SOLID-PHASE EXTRACTION LIQUID-CHROMATOGRAPHY ELECTROCHEMICAL DETECTION SODIUM-BOROHYDRIDE TOBACCO ALKALOIDS PLASMA REDUCTION PRODUCTS CHEMILUMINESCENCE |
| ISSN号 | 0173-0835 |
| 通讯作者 | you ty |
| 中文摘要 | in this paper, ce coupled with electrochemiluminesence (ecl) detection using a 76-mu m pt disk as working electrode was developed for nicotine (nic) determination. the major metabolite of nic is cotinine (cot), which has a similar tertiary amine structure to nic. however, there is a carbonyl group attached in the structure of cot, which leads to the great decrease in ecl response. in order to improve the ecl response of cot, nabh(4) was used for carbonyl reduction. after reduction, nic and cot were separated and detected by ce-ecl. ecl response plotted with nic concentration was linear between 5.0 x 10(-7) and 5.0 x 10(-5) mol/l (81-8100 mu g/l), with lod of 5.0 x 10(-8) mol/l (8.1 mu g/l). the developed ce-ecl method was applied for nic determination in urine and cigarette samples. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294180800010 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44422]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun JY,Du HW,You TY. Determination of nicotine and its metabolite cotinine in urine and cigarette samples by capillary electrophoresis coupled with electrochemiluminescence[J]. electrophoresis,2011,32(16):2148-2154. |
| APA | Sun JY,Du HW,&You TY.(2011).Determination of nicotine and its metabolite cotinine in urine and cigarette samples by capillary electrophoresis coupled with electrochemiluminescence.electrophoresis,32(16),2148-2154. |
| MLA | Sun JY,et al."Determination of nicotine and its metabolite cotinine in urine and cigarette samples by capillary electrophoresis coupled with electrochemiluminescence".electrophoresis 32.16(2011):2148-2154. |
入库方式： OAI收割
来源：长春应用化学研究所
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