Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil
文献类型：期刊论文
| 作者 | Yan SF ; Zhu J ; Wang ZC ; Yin JB ; Zheng YZ ; Chen XS |
| 刊名 | european journal of pharmaceutics and biopharmaceutics
 |
| 出版日期 | 2011 |
| 卷号 | 78期号:3页码:336-345 |
| 关键词 | POLYELECTROLYTE MULTILAYER CAPSULES DRUG-DELIVERY SYSTEMS IN-VITRO SPONTANEOUS DEPOSITION ACID) MICROSPHERES CHITOSAN NANOPARTICLES MACROMOLECULES ENCAPSULATION PERMEABILITY |
| ISSN号 | 0935-1221 |
| 通讯作者 | yin jb |
| 中文摘要 | hollow polyelectrolyte microcapsules based on poly(l-glutamic acid) (plga) and chitosan (cs) with opposite charges were fabricated by layer-by-layer (lbl) assembly technique using melamine formaldehyde (mf) microparticles as sacrificial templates. the lbl assembly of polyelectrolytes and the resultant plga/cs microcapsules were characterized. a hydrophilic anticancer drug, 5-fluorouracil (5-fu), was chosen to investigate the loading and release properties of the microcapsules. the plga/cs microcapsules show high loading capacity of 5-fu under conditions of high drug concentration and salt adding. the high loading can be ascribed to spontaneous deposition of 5-fu induced by hydrogen bonding between 5-fu and plga/cs microcapsules. the plga/cs microcapsules show sustained release behavior. the release rate of 5-fu drastically slows down after loading in plga/cs microcapsules. the 5-fu release from plga/cs microcapsules can be best described using ritger-peppas or baker-londale models, indicating the diffusion mechanism of 5-fu release from the plga/cs microcapsules. in vitro cytotoxicity evaluation by the mtt assay shows good cell viability over the entire concentration range of plga/cs microcapsules. therefore, the novel plga/cs microcapsules are expected to find application in drug delivery systems because of the properties of biodegradability, high loading, sustained release and cell compatibility. (c) 2010 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000294105600005 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44425]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yan SF,Zhu J,Wang ZC,et al. Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil[J]. european journal of pharmaceutics and biopharmaceutics,2011,78(3):336-345. |
| APA | Yan SF,Zhu J,Wang ZC,Yin JB,Zheng YZ,&Chen XS.(2011).Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil.european journal of pharmaceutics and biopharmaceutics,78(3),336-345. |
| MLA | Yan SF,et al."Layer-by-layer assembly of poly(L-glutamic acid)/chitosan microcapsules for high loading and sustained release of 5-fluorouracil".european journal of pharmaceutics and biopharmaceutics 78.3(2011):336-345. |
入库方式： OAI收割
来源：长春应用化学研究所
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