Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes
文献类型：期刊论文
| 作者 | Mo GJ ; Yue J ; Ma PA ; Chen XS ; Huang YB ; Jing XB |
| 刊名 | polymer international
 |
| 出版日期 | 2011 |
| 卷号 | 60期号:8页码:1269-1276 |
| 关键词 | ANTICANCER DRUG-DELIVERY ALIPHATIC POLYESTERS COPOLYMER MICELLES DOXORUBICIN PROTEINS PH POLY(CARBONATE-ESTER)S CARBONATE CANCER |
| ISSN号 | 0959-8103 |
| 通讯作者 | jing xb |
| 中文摘要 | amphiphilic amino-bearing biodegradable copolymers, [methoxy-poly(ethylene glycol)]-block-poly[(l-lactide)-co-(serinol carbonate)] (mpeg-block-p(la-co-ca)), are prepared by synthesizing amino-bearing cyclic carbonate monomer n-benzoxycarbonylserinol carbonate (cab) starting from serinol, by ring-opening polymerization of l-lactide and cab using diethylzinc as catalyst and mpeg as macroinitiator, and by subsequent removal of the protective benzyloxycarbonyl groups by hbr treatment. after deprotection, the pendant amino groups on the carbonate units are reacted with n-hydroxylsuccinimide-activated folic acid (fa) to achieve mpeg-block-p(la-co-ca/fa) conjugate and with fluorescein isothiocyanate (fitc) to achieve mpeg-block-p(la-co-ca/fitc) conjugate. the structures of mpeg-block-p(la-co-cab), mpeg-block-p(la-co-ca), mpeg-block-p(la-co-ca/fa) and mpeg-block-p(la-co-ca/fitc) are confirmed using h-1 nmr and fourier transform infrared spectroscopy. the block copolymers can self-assemble into micelles in aqueous solution. because of the functionality of fa and fitc, these copolymers can find important applications in drug delivery systems to serve as targeting moieties and fluorescent probes. (c) 2011 society of chemical industry |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293963300018 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44430]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Mo GJ,Yue J,Ma PA,et al. Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes[J]. polymer international,2011,60(8):1269-1276. |
| APA | Mo GJ,Yue J,Ma PA,Chen XS,Huang YB,&Jing XB.(2011).Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes.polymer international,60(8),1269-1276. |
| MLA | Mo GJ,et al."Synthesis and characterization of amphiphilic block polymers with amino groups and their conjugates with folic acid and fluorescent probes".polymer international 60.8(2011):1269-1276. |
入库方式： OAI收割
来源：长春应用化学研究所
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