Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers
文献类型：期刊论文
| 作者 | Li TH ; Jing XB ; Huang YB |
| 刊名 | polymers for advanced technologies
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:8页码:1266-1271 |
| 关键词 | LIPOSOME-ENCAPSULATED HEMOGLOBIN IN-VITRO VESICLES SUBSTITUTE CELLS |
| ISSN号 | 1042-7147 |
| 通讯作者 | huang yb |
| 中文摘要 | amphiphilic triblock copolymers were synthesized using mpeg, cyclic carbonic ester monomer including propargyl group (mpc) and l-lactide (la). these copolymers could self-assemble into core-shell spherical micelles with propargyl groups on the surface. azided hemoglobin (hb) was conjugated with the micelles through click reaction to form hb-bearing nano-micelles. the click reaction conditions, such as the molar ratio of sodium azide to hb, the binding ratio of hb to copolymers, the components of catalytic solution, the reaction temperature and time, were thoroughly investigated and optimized. the resulted nano-micelles had 100 nm diameter with 50-60 wt% of hb content. the hb-based nano-micelles showed appropriate stability and oxygen carrying capacity, and would have the potential to be used as the new type of artificial oxygen carrier. copyright (c) 2011 john wiley & sons, ltd. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293596700011 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44437]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li TH,Jing XB,Huang YB. Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers[J]. polymers for advanced technologies,2011,22(8):1266-1271. |
| APA | Li TH,Jing XB,&Huang YB.(2011).Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers.polymers for advanced technologies,22(8),1266-1271. |
| MLA | Li TH,et al."Synthesis of the hemoglobin-conjugated polymer micelles by click chemistry as the oxygen carriers".polymers for advanced technologies 22.8(2011):1266-1271. |
入库方式： OAI收割
来源：长春应用化学研究所
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