Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions
文献类型：期刊论文
| 作者 | Zhao CQ ; Geng J ; Feng LY ; Ren JS ; Qu XG |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2011 |
| 卷号 | 17期号:29页码:8209-8215 |
| 关键词 | INTRAMOLECULAR G-QUADRUPLEX CONFORMATIONAL SWITCH SMALL-MOLECULE K+ SOLUTION DNA BINDING TELOMESTATIN LIGANDS ENANTIOMERS RESOLUTION |
| ISSN号 | 0947-6539 |
| 通讯作者 | qu xg |
| 中文摘要 | chiral molecular recognition of human telomeric dna is important for rational drug design and developing structural probes of g-quadruplexes. here we report that a chiral supramolecular complex can selectively induce human telomeric g-quadruplex formation and discriminate different g-quadruplex sequences under salt-deficient conditions studied by circular dichroism (cd), uv meltings, stopped-flow spectroscopy, fluorescence resonance energy transfer, enzyme cleavage, and gel electrophoresis. p-enantiomer induced g-quadruplex formation is fast and does not require a large excess of p enantiomer. more importantly, this chiral compound induces loop sequence-dependent g-quadruplex formation. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000293702500032 |
| 公开日期 | 2012-06-08 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44505]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao CQ,Geng J,Feng LY,et al. Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions[J]. chemistry-a european journal,2011,17(29):8209-8215. |
| APA | Zhao CQ,Geng J,Feng LY,Ren JS,&Qu XG.(2011).Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions.chemistry-a european journal,17(29),8209-8215. |
| MLA | Zhao CQ,et al."Chiral Metallo-Supramolecular Complexes Selectively Induce Human Telomeric G-Quadruplex Formation under Salt-Deficient Conditions".chemistry-a european journal 17.29(2011):8209-8215. |
入库方式： OAI收割
来源：长春应用化学研究所
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