中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
RGD-Conjugated Copolymer Incorporated into Composite of Poly(lactide-co-glycotide) and Poly(L-lactide)-Grafted Nanohydroxyapatite for Bone Tissue Engineering

文献类型:期刊论文

作者Zhang PB ; Wu HT ; Wu H ; Lu ZW ; Deng C ; Hong ZK ; Jing XB ; Chen XS
刊名biomacromolecules
出版日期2011
卷号12期号:7页码:2667-2680
关键词ACID) TRIBLOCK COPOLYMER OSTEOBLAST ADHESION IN-VITRO CELL ATTACHMENT HYDROXYAPATITE SCAFFOLDS PEPTIDES DIFFERENTIATION BIOMATERIALS BIOCOMPATIBILITY
ISSN号1525-7797
通讯作者chen xs
中文摘要various surface modification methods of rgd (arg-gly-asp) peptides on biomaterials have been developed to improve cell adhesion. this study aimed to examine a rgd-conjugated copolymer rgd/mpeg-pla-pblg (rgd-copolymer) for its ability to promote bone regeneration by mixing it with the composite of poly(lactide-co-glycotide) (plga) and hydroxyapatite nanoparticles surface grafted with poly(l-lactide) (g-hap). the porous scaffolds were prepared using solvent casting/particulate leaching method and grafted to repair the rabbit radius defects after seeding with autologous bone marrow mesenchymal cells (mscs) of rabbits. after incorporation of rgd-copolymer, there were no significant influences on scaffold's porosity and pore size. nitrogen of rgd peptide, and calcium and phosphor of g-hap could be exposed on the surface of the scaffold simultaneously. although the cell viability of its leaching liquid was 92% that was lower than g-hap/plga, its cell adhesion and growth of 3t3 and osteoblasts were promoted;significantly. the greatest increment in cell adhesion ratios (131.2-157.1% higher than g-hap/plga) was observed when its contents were 0.1-1 wt % but only at 0.5 h after cell seeding. all the defects repaired with the implants were bridged after 24 weeks postsurgery, but the rgd-copolymer contained composite had larger new bone formation and better fusion interface. the composites containing rgd-copolymer enhanced bone ingrowth but presented more woven bones than others. the combined application of rgd-copolymer and bone morphological protein 2 (bmp-2) exhibited the best bone healing quality and was recommended as an optimal strategy for the use of rgd peptides.
收录类别SCI收录期刊论文
语种英语
WOS记录号WOS:000292617700029
公开日期2012-06-08
源URL[http://ir.ciac.jl.cn/handle/322003/44512]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Zhang PB,Wu HT,Wu H,et al. RGD-Conjugated Copolymer Incorporated into Composite of Poly(lactide-co-glycotide) and Poly(L-lactide)-Grafted Nanohydroxyapatite for Bone Tissue Engineering[J]. biomacromolecules,2011,12(7):2667-2680.
APA Zhang PB.,Wu HT.,Wu H.,Lu ZW.,Deng C.,...&Chen XS.(2011).RGD-Conjugated Copolymer Incorporated into Composite of Poly(lactide-co-glycotide) and Poly(L-lactide)-Grafted Nanohydroxyapatite for Bone Tissue Engineering.biomacromolecules,12(7),2667-2680.
MLA Zhang PB,et al."RGD-Conjugated Copolymer Incorporated into Composite of Poly(lactide-co-glycotide) and Poly(L-lactide)-Grafted Nanohydroxyapatite for Bone Tissue Engineering".biomacromolecules 12.7(2011):2667-2680.

入库方式: OAI收割

来源:长春应用化学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。