Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly
文献类型：期刊论文
| 作者 | Ding JX ; Xiao CS ; Zhao L ; Cheng YL ; Ma LL ; Tang ZH ; Zhuang XL ; Chen XS |
| 刊名 | journal of polymer science part a-polymer chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 49期号:12页码:2665-2676 |
| 关键词 | TRANSFER RADICAL POLYMERIZATION ETHER METHACRYLATES BLOCK-COPOLYMERS DRUG-DELIVERY PH TEMPERATURE WATER POLYPEPTIDES POLYMERS POLY(N-ISOPROPYLACRYLAMIDE) |
| ISSN号 | 0887-624x |
| 通讯作者 | chen xs |
| 中文摘要 | thermoresponsive and ph-responsive graft copolymers, poly(l-glutamate)-g-oligo(2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate) and poly(l-glutamic acid-co-(l-glutamate-g-oligo(2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate))), were synthesized by ring-opening polymerization (rop) of n-carboxyanhydride (nca) monomers and subsequent atom transfer radical polymerization of 2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate. the thermoresponsiveness of graft copolymers could be tuned by the molecular weight of oligo(2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate) (omeo(3)ma), composition of poly(l-glutamic acid) (plga) backbone and ph of the aqueous solution. the alpha-helical contents of graft copolymers could be influenced by omeo(3)ma length and ph of the aqueous solution. in addition, the graft copolymers exhibited tunable self-assembly behavior. the hydrodynamic radius (r(h)) and critical micellization concentration values of micelles were relevant to the length of omeo(3)ma and the composition of biodegradable plga backbone. the r(h) could also be adjusted by the temperature and ph values. lastly, in vitro methyl thiazolyl tetrazolium (mtt) assay revealed that the graft copolymers were biocompatible to hela cells. therefore, with good biocompatibility, well-defined secondary structure, and mono-, dual-responsiveness, these graft copolymers are promising stimuli-responsive materials for biomedical applications. (c) 2011 wiley periodicals, inc. j polym sci part a: polym chem 49: 2665-2676, 2011 |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000290760100015 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44574]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Xiao CS,Zhao L,et al. Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly[J]. journal of polymer science part a-polymer chemistry,2011,49(12):2665-2676. |
| APA | Ding JX.,Xiao CS.,Zhao L.,Cheng YL.,Ma LL.,...&Chen XS.(2011).Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly.journal of polymer science part a-polymer chemistry,49(12),2665-2676. |
| MLA | Ding JX,et al."Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly".journal of polymer science part a-polymer chemistry 49.12(2011):2665-2676. |
入库方式： OAI收割
来源：长春应用化学研究所
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