A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides
文献类型：期刊论文
| 作者 | Zhao YL ; Li Y ; Li SM ; Zhou YG ; Sun FY ; Gao LX ; Han FS |
| 刊名 | advanced synthesis & catalysis
 |
| 出版日期 | 2011 |
| 卷号 | 353期号:9页码:1543-1550 |
| 关键词 | STERICALLY HINDERED BIARYLS ACTIVE PALLADIUM CATALYSTS C-O ACTIVATION ARYLBORONIC ACIDS BORONIC ACIDS ROOM-TEMPERATURE COMPLEXES ARENESULFONATES CHLORIDES CHLOROARENES |
| ISSN号 | 1615-4150 |
| 通讯作者 | han fs |
| 中文摘要 | we disclose that [1,3-bis(diphenylphosphino)methane]nickel(ii) chloride [nicl(2)(dppp)] is a highly active, universally applicable, cheap, and stable catalyst for suzuki-miyaura cross-coupling reactions of aryl halides with a catalyst loading of lower than 1 mol%, and more notably, in the absence of extra supporting ligands. under the optimized reaction conditions, a broad range of aryl bromides as well as the notoriously unreactive aryl chlorides, including activated, non-activated, deactivated, and heteroaromatic and sterically hindered substrates can be coupled smoothly with various boronic acids (47 examples, 48-98% yields). in addition, the transformation is tolerant of various functional groups such as ether, ester, ketone, aldehyde, cyano, and un-protected amino and hydroxy groups. finally, the potential utilization of the methodology was further demonstrated by the gram-scale synthesis of several core structures of commercialized antihypertensive drugs and fungicides. thus, the combination of high activity, broad applicability, cheapness, and high stability of nicl(2)(dppp) presented in this work constitutes one of the few prominent catalysts which allow for practical and reliable construction of biaryls and heterobiaryls with structural diversity from readily available aryl halides and boronic acids. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000292848200025 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44594]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao YL,Li Y,Li SM,et al. A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides[J]. advanced synthesis & catalysis,2011,353(9):1543-1550. |
| APA | Zhao YL.,Li Y.,Li SM.,Zhou YG.,Sun FY.,...&Han FS.(2011).A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides.advanced synthesis & catalysis,353(9),1543-1550. |
| MLA | Zhao YL,et al."A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides".advanced synthesis & catalysis 353.9(2011):1543-1550. |
入库方式： OAI收割
来源：长春应用化学研究所
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