Monodisperse core-shell structured up-conversion Yb(OH)CO(3)@YbPO(4):Er(3+) hollow spheres as drug carriers
文献类型：期刊论文
| 作者 | Xu ZH ; Ma PA ; Li CX ; Hou ZY ; Zhai XF ; Huang SS ; Lin J |
| 刊名 | biomaterials
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:17页码:4161-4173 |
| 关键词 | MESOPOROUS SILICA NANOSPHERES BIOMEDICAL APPLICATIONS FLUORESCENT NANOPARTICLES SPHERICAL COLLOIDS NANOCRYSTALS PARTICLES DELIVERY LUMINESCENCE FABRICATION KIRKENDALL |
| ISSN号 | 0142-9612 |
| 通讯作者 | lin j |
| 中文摘要 | in this work, we report a facile solution-phase synthesis of monodisperse core-shell structured yb(oh)co(3)@ybpo(4) hollow spheres (size around 380 nm) by utilizing the colloidal sphere of yb(oh)co(3) as the sacrificial template via the kirkendall effect. the er(3+) doped yb(oh)co(3)@ybpo(4) core-shell hollow spheres can be prepared similarly, which exhibit strong green emission under 980 nm nir laser excitation even after loading with drug molecules. most importantly, the sample can be used as an effective drug delivery carrier. the biocompatibility test on l929 fibroblast cells using mu assay reveals low cytotoxicity of the system. a typical anticancer drug, doxorubicin hydrochloride (dox), is used for drug loading, and the release properties, cytotoxicity, uptake behavior and therapeutic effects were examined. it is found that dox is shuttled into cell by core-shell hollow spheres carrier and released inside cells after endocytosis, and the dox-loaded spheres exhibited greater cytotoxicity than free dox. these results indicate that the core-shell er(3+) doped yb(oh)co(3)@ybpo(4) hollow spheres have potential for drug loading and delivery into cancer cells to induce cell death. (c) 2011 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44607]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu ZH,Ma PA,Li CX,et al. Monodisperse core-shell structured up-conversion Yb(OH)CO(3)@YbPO(4):Er(3+) hollow spheres as drug carriers[J]. biomaterials,2011,32(17):4161-4173. |
| APA | Xu ZH.,Ma PA.,Li CX.,Hou ZY.,Zhai XF.,...&Lin J.(2011).Monodisperse core-shell structured up-conversion Yb(OH)CO(3)@YbPO(4):Er(3+) hollow spheres as drug carriers.biomaterials,32(17),4161-4173. |
| MLA | Xu ZH,et al."Monodisperse core-shell structured up-conversion Yb(OH)CO(3)@YbPO(4):Er(3+) hollow spheres as drug carriers".biomaterials 32.17(2011):4161-4173. |
入库方式： OAI收割
来源：长春应用化学研究所
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