Mesoporous carbon microparticles as a novel fluorescent sensing platform for thrombin detection
文献类型：期刊论文
| 作者 | Zhang YW ; Liu S ; Sun XP |
| 刊名 | biosensors & bioelectronics
 |
| 出版日期 | 2011 |
| 卷号 | 26期号:9页码:3876-3880 |
| 关键词 | SWITCHING SIGNALING APTAMERS MOLECULAR RECOGNITION SENSITIVE DETECTION PROTEIN DNA NANOPARTICLES GRAPHENE PROBES NANOSTRUCTURES MESOSTRUCTURE |
| ISSN号 | 0956-5663 |
| 通讯作者 | sun xp |
| 中文摘要 | the present paper presents the novel use of mc microparticles (mcmps) as a novel fluorescent sensing platform for thrombin detection. the mcmps were prepared by a nanocasting method using mesoporous silica (ms) nps as a hard template. the general concept used in this approach lies in the facts that the non-covalent adsorption of the dye-labeled ta on mcmp driven by pi-pi stacking of dna bases on mcmp leads to substantial quenching of dye fluorescence due to their very close proximity. however, the presence of target tb results in the change of ta conformation to quadruplex due to the quadruplex-tb complex formation. because the binding between the complex and mcmp is not strong enough to guarantee the close proximity of dyes to mcmp surface, fluorescence quenching is suppressed. this sensing system has a low detection limit down to 0.25 nm and exhibits excellent selectivity. we also demonstrate its application in human blood serum system. (c) 2011 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000291178200024 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44629]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang YW,Liu S,Sun XP. Mesoporous carbon microparticles as a novel fluorescent sensing platform for thrombin detection[J]. biosensors & bioelectronics,2011,26(9):3876-3880. |
| APA | Zhang YW,Liu S,&Sun XP.(2011).Mesoporous carbon microparticles as a novel fluorescent sensing platform for thrombin detection.biosensors & bioelectronics,26(9),3876-3880. |
| MLA | Zhang YW,et al."Mesoporous carbon microparticles as a novel fluorescent sensing platform for thrombin detection".biosensors & bioelectronics 26.9(2011):3876-3880. |
入库方式： OAI收割
来源：长春应用化学研究所
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