Preparation and Osteogenesis Activities of Electroactive Biodegradable Nanocomposites PAP/op-HA/PLGA
文献类型：期刊论文
| 作者 | Wu HT ; Yu T ; Zhu QS ; Rao ZX ; Wei Y ; Zhang PB ; Chen XS |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:5页码:1181-1187 |
| 关键词 | TISSUE ENGINEERING APPLICATIONS ANILINE PENTAMER CONDUCTING POLYMERS BLOCK-COPOLYMER POLYLACTIDE CELLS |
| ISSN号 | 0251-0790 |
| 通讯作者 | zhu qs |
| 中文摘要 | the electroactive biodegradable nanocomposites pap/op-ha/plga were prepared by blending a triblock copolymer pla-b-ap-b-pla( pap) of polylactide( pea) and aniline pentamer(ap) with oligomeric lactic acid-surface grafted hydroxyapatite(op-ha)/poly(lactide-co-glycolide) (ma). the electrochemical properties and conductivity, were characterized using uv-vis spectroscopy, cyclic voltammetry and standard four-probe method. the film's surface morphology was displayed by esem and the contact angle was measured to evaluate the film's hydrophilicity. rabbit's osteoblasts were cultured in vitro on the film surface. for comprehensively evaluating surface properties and biological activity of the new electroactive nanocomposites pap/op-ha/plga for bone repair, cell adhesion and cell spreading (cell area fraction) were determined using fluorescein isothiocyanate dyeing and nw image j software analysis, and gene expression levels were detected using real-time pcb. the results show that pap/op-ha/plga composites have good electrochemical redox property and low conductivity(5 x 10(6) s/cm). with the mass fraction of 0.1% pap, the hydrophilicity of composites was improved, the adhesion and expansion of osteoblasts were enhanced, and bone morphogenetic protein-2(bmp-2) and bone junction protein(osteonectin) gene expression levels were increased, significantly. in conclusion, pap/op-ha/plga composites have good biocompatibility and osteogenic activity. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 中文 |
| WOS记录号 | WOS:000291175800034 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44641]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu HT,Yu T,Zhu QS,et al. Preparation and Osteogenesis Activities of Electroactive Biodegradable Nanocomposites PAP/op-HA/PLGA[J]. chemical journal of chinese universities-chinese,2011,32(5):1181-1187. |
| APA | Wu HT.,Yu T.,Zhu QS.,Rao ZX.,Wei Y.,...&Chen XS.(2011).Preparation and Osteogenesis Activities of Electroactive Biodegradable Nanocomposites PAP/op-HA/PLGA.chemical journal of chinese universities-chinese,32(5),1181-1187. |
| MLA | Wu HT,et al."Preparation and Osteogenesis Activities of Electroactive Biodegradable Nanocomposites PAP/op-HA/PLGA".chemical journal of chinese universities-chinese 32.5(2011):1181-1187. |
入库方式： OAI收割
来源：长春应用化学研究所
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