Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MS(n)
文献类型：期刊论文
| 作者 | Han TJ ; Wang Q ; Song FR ; Liu ZY ; Liu ZQ ; Liu SY |
| 刊名 | chemical research in chinese universities
 |
| 出版日期 | 2011 |
| 卷号 | 27期号:3页码:380-384 |
| 关键词 | CELL-SUSPENSION CULTURES CYTOTOXIC BUFADIENOLIDES PLATYCODON-GRANDIFLORUM LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY ABSORPTION MONOLAYERS PRODUCTS BUFALIN |
| ISSN号 | 1005-9040 |
| 通讯作者 | liu zq |
| 中文摘要 | in vitro models of human colon carcinoma cell line(caco-2 cell monolayer) and human intestinal bacteria were used to investigate the intestinal transport and biotransformation of resibufogenin and cinobufagin in chan su by hplc/apci-ms(n). the experimental results of caco-2 cell monolayer demonstrate that the apparent permeability coefficients(p(app)) of resibufogenin and cinobufagin are higher than 10(-6) cm/s, which indicates that both resibufogenin and cinobufagin have a good absorption in the small intestine. and the biotransformation result of human intestinal bacteria shows that resibufogenin has been transformed to 3-epiresibufogenin and cinobufagin has been transformed to 3-epicinobufagin, deacetylcinobufagin and 3-epideacetycinobufagin, respectively. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44657]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Han TJ,Wang Q,Song FR,et al. Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MS(n)[J]. chemical research in chinese universities,2011,27(3):380-384. |
| APA | Han TJ,Wang Q,Song FR,Liu ZY,Liu ZQ,&Liu SY.(2011).Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MS(n).chemical research in chinese universities,27(3),380-384. |
| MLA | Han TJ,et al."Intestinal Transport and Biotransformation of Resibufogenin and Cinobufagin in Chan Su via HPLC/APCI-MS(n)".chemical research in chinese universities 27.3(2011):380-384. |
入库方式： OAI收割
来源：长春应用化学研究所
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