Exploring the Thermodynamic Landscape, Kinetics, and Structural Evolution of a Protein Conformational Transition with a Microscopic Double-Well Model
文献类型：期刊论文
| 作者 | Lai ZZ ; Lu QA ; Wang J |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2011 |
| 卷号 | 115期号:14页码:4147-4159 |
| 关键词 | GLUTAMINE-BINDING PROTEIN ENERGY LANDSCAPE DYNAMICS MECHANISM FLUORESCENCE KINASE STATE |
| ISSN号 | 1520-6106 |
| 通讯作者 | wang j |
| 中文摘要 | functional conformational transition in the glutamine-binding protein (glnbp) is known to be the key to bind and transfer ligand glutamine. here, we developed a structure-based double-well model to investigate the thermodynamic and kinetic natures of the glnbp conformational transition. we uncovered the underlying free-energy landscape of the conformational transition with different temperatures. the analysis shows that below the melting temperature, two basins of attractions emerge, corresponding to the open state and the closed state of the protein. we explored the kinetic property of the conformational switch through the mean and distribution of the first passage time as well as the autocorrelation function. the kinetics implies the complexity and the hierarchical structure of the underlying energy landscape. we built the contact maps of the structures to probe the structural evolution of the conformational transition. finally, the phi values of the residues were calculated to identify the important residues (hot spots) of the transition state. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000289215600043 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44706]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lai ZZ,Lu QA,Wang J. Exploring the Thermodynamic Landscape, Kinetics, and Structural Evolution of a Protein Conformational Transition with a Microscopic Double-Well Model[J]. journal of physical chemistry b,2011,115(14):4147-4159. |
| APA | Lai ZZ,Lu QA,&Wang J.(2011).Exploring the Thermodynamic Landscape, Kinetics, and Structural Evolution of a Protein Conformational Transition with a Microscopic Double-Well Model.journal of physical chemistry b,115(14),4147-4159. |
| MLA | Lai ZZ,et al."Exploring the Thermodynamic Landscape, Kinetics, and Structural Evolution of a Protein Conformational Transition with a Microscopic Double-Well Model".journal of physical chemistry b 115.14(2011):4147-4159. |
入库方式： OAI收割
来源：长春应用化学研究所
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