Oligoethylenimines Grafted to PEGylated Poly(beta-amino ester)s for Gene Delivery
文献类型：期刊论文
| 作者 | Xia JL ; Tian HY ; Chen L ; Lin L ; Guo ZP ; Chen J ; Chen XS |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2011 |
| 卷号 | 12期号:4页码:1024-1031 |
| 关键词 | LOW-MOLECULAR-WEIGHT DNA DELIVERY IN-VIVO POLY(ETHYLENE IMINE) PLASMID DNA POLYETHYLENIMINE CARRIER TRANSFECTION VECTORS POLYPLEXES |
| ISSN号 | 1525-7797 |
| 通讯作者 | chen xs |
| 中文摘要 | novel polymers composed of net-like pegylated poly(beta-amino ester) (n-p-1, m(w) = 6900 or n-p-2, m(w) = 21 400) and oligoethylenimine (oei) (oei423 or oei600) were synthesized and evaluated as gene carriers. the molecular weights of these polymers were well-controlled by the concentration of the cross-linking reaction. the synthesized polymers showed high biodegradability, less cytotoxicity, and efficient dna retard ability. the n-p-1-oei600/dna complex showed much slower aggregation in the presence of 10 and 20% serum solutions. in vitro transfection assays, n-p-2-oei423, n-p-1-oei600, and n-p-2-oei600 showed enhanced transfection efficiency compared with the pei25k control in the presence or in the absence of serum in different cell lines. in particular, in cos-7 cells, the transfection efficiency of n-p-1-oei600 was 20.9 times higher than that of pei25k in the presence of serum. the polymer/dna complex stability, lower cytotoxicity, and higher transfection efficiency in the presence of serum revealed that n-p-1-oei600 could be a potential nonviral gene carrier for in vivo application.: |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000289223500020 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44723]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xia JL,Tian HY,Chen L,et al. Oligoethylenimines Grafted to PEGylated Poly(beta-amino ester)s for Gene Delivery[J]. biomacromolecules,2011,12(4):1024-1031. |
| APA | Xia JL.,Tian HY.,Chen L.,Lin L.,Guo ZP.,...&Chen XS.(2011).Oligoethylenimines Grafted to PEGylated Poly(beta-amino ester)s for Gene Delivery.biomacromolecules,12(4),1024-1031. |
| MLA | Xia JL,et al."Oligoethylenimines Grafted to PEGylated Poly(beta-amino ester)s for Gene Delivery".biomacromolecules 12.4(2011):1024-1031. |
入库方式： OAI收割
来源：长春应用化学研究所
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