Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery
文献类型：期刊论文
| 作者 | Yu HJ ; Deng C ; Tian HY ; Lu TC ; Chen XS ; Jing XB |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:3页码:352-361 |
| 关键词 | PLASMID DNA IN-VIVO POLYETHYLENIMINE PEI SIRNA DELIVERY POLYPLEXES POLYMERS VECTORS CELLS CARRIERS POLY(GLYCOAMIDOAMINE)S |
| ISSN号 | 1616-5187 |
| 通讯作者 | jing xb |
| 中文摘要 | for the success of non-viral gene delivery, it is of great importance to develop gene vectors with high efficiency but low toxicity. we demonstrate that pll-grafted chitosan copolymers combine the advantages of pll with its good pdna-binding ability and of chitosan with its good biocompatibility. the chemo-physical properties of the prepared chi-g-pll copolymers are thoroughly characterized. the in vitro transfection study shows that the copolymers have a much higher gene transfer ability than the starting materials chitosan and pll. a positive correlation between pll chain lengths and transfection efficiency of the copolymers is found. our results suggest that these novel chi-g-pll copolymers are good candidates for gene delivery in vivo. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000288034800005 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44772]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu HJ,Deng C,Tian HY,et al. Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery[J]. macromolecular bioscience,2011,11(3):352-361. |
| APA | Yu HJ,Deng C,Tian HY,Lu TC,Chen XS,&Jing XB.(2011).Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery.macromolecular bioscience,11(3),352-361. |
| MLA | Yu HJ,et al."Chemo-Physical and Biological Evaluation of Poly( L-lysine)-Grafted Chitosan Copolymers Used for Highly Efficient Gene Delivery".macromolecular bioscience 11.3(2011):352-361. |
入库方式： OAI收割
来源：长春应用化学研究所
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