Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers
文献类型：期刊论文
| 作者 | Chen CE ; Pu F ; Huang ZZ ; Liu Z ; Ren JS ; Qu XG |
| 刊名 | nucleic acids research
 |
| 出版日期 | 2011 |
| 卷号 | 39期号:4页码:1638-1644 |
| 关键词 | MESOPOROUS SILICA NANOSPHERE FUNCTIONALIZATION NEUROTRANSMITTERS NANOPARTICLES NANOVALVES SWITCH |
| ISSN号 | 0305-1048 |
| 通讯作者 | ren js |
| 中文摘要 | a novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex dna as caps onto pore outlets of mesoporous silica nanoparticles. start from simple conformation changes, the i-motif dna cap can open and close the pore system in smart response to ph stimulus. importantly, the opening/closing and delivery protocol is highly reversible and a partial cargo delivery can be easily controlled at will. a ph-switchable nanoreactor has also been developed to validate the potential of our system for on-demand molecular transport. this proof of concept might open the door to a new generation of carrier materials and could also provide a general route to use other functional nucleic acids/peptide nucleic acids as capping agents in the fields of versatile controlled delivery nanodevices. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000288019400047 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44783]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen CE,Pu F,Huang ZZ,et al. Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers[J]. nucleic acids research,2011,39(4):1638-1644. |
| APA | Chen CE,Pu F,Huang ZZ,Liu Z,Ren JS,&Qu XG.(2011).Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers.nucleic acids research,39(4),1638-1644. |
| MLA | Chen CE,et al."Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers".nucleic acids research 39.4(2011):1638-1644. |
入库方式： OAI收割
来源：长春应用化学研究所
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