Nickel-Catalyzed Cross-Coupling of Phenols and Arylboronic Acids Through an In Situ Phenol Activation Mediated by PyBroP
文献类型：期刊论文
| 作者 | Chen GJ ; Huang J ; Gao LX ; Han FS |
| 刊名 | chemistry-a european journal
 |
| 出版日期 | 2011 |
| 卷号 | 17期号:14页码:4038-4042 |
| 关键词 | ARYL GRIGNARD-REAGENTS C-O ACTIVATION SUZUKI-MIYAURA BORONIC ACIDS BOND FORMATION EFFICIENT AMINATION MESYLATES ARENESULFONATES COMPLEXES |
| ISSN号 | 0947-6539 |
| 通讯作者 | han fs |
| 中文摘要 | a new method for the suzuki-miyaura cross-coupling of phenols and arylboronic acids through in situ phenol activation mediated by pybrop is presented. the reaction proceeds efficiently by using cost-effective, markedly stable [nicl(2)(dppp)] (dppp = 1,3-bis(diphenylphosphino) propane) as the catalyst in only 5 mol% loading, as well as in the absence of extra ligands. the method exhibits broad applicability and high efficiency towards a wide range of both phenols and boronic acids, including activated, nonactivated, deactivated, and heteroaromatic coupling partners. in addition, various functional groups, such as ether, amino, cyano, ester, and ketone groups, are compatible with this transformation. notably, arylboronic acids containing an unprotected nh(2) group and 2-heterocyclic boronic acids, which are generally problematic for coupling under conventional conditions, are also viable substrates, although moderate yields were obtained for sterically hindered substrates. consequently, the in situ cross-coupling methodology coupled with the use of an inexpensive and stable nickel catalyst provides a rapid and efficient pathway for the assembly of biaryls and heterobiaryls with structural diversity from readily available phenol compounds. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000288566700030 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44785]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen GJ,Huang J,Gao LX,et al. Nickel-Catalyzed Cross-Coupling of Phenols and Arylboronic Acids Through an In Situ Phenol Activation Mediated by PyBroP[J]. chemistry-a european journal,2011,17(14):4038-4042. |
| APA | Chen GJ,Huang J,Gao LX,&Han FS.(2011).Nickel-Catalyzed Cross-Coupling of Phenols and Arylboronic Acids Through an In Situ Phenol Activation Mediated by PyBroP.chemistry-a european journal,17(14),4038-4042. |
| MLA | Chen GJ,et al."Nickel-Catalyzed Cross-Coupling of Phenols and Arylboronic Acids Through an In Situ Phenol Activation Mediated by PyBroP".chemistry-a european journal 17.14(2011):4038-4042. |
入库方式： OAI收割
来源：长春应用化学研究所
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