Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization
文献类型：期刊论文
| 作者 | Guo JS ; Wei Y ; Zhou DF ; Cai PQ ; Jing XB ; Chen XS ; Huang YB |
| 刊名 | biomacromolecules
 |
| 出版日期 | 2011 |
| 卷号 | 12期号:3页码:737-746 |
| 关键词 | PEPTIDE-BASED POLYMERS PENDANT AMINO-GROUPS RADICAL POLYMERIZATION MATERIALS SCIENCE CHEMISTRY CYCLOADDITION AZIDES ARCHITECTURES COPOLYMERS LIGATION |
| ISSN号 | 1525-7797 |
| 通讯作者 | huang yb |
| 中文摘要 | poly(epsilon-lysine) (epsilon-pl)-analogous click polypeptides with not only similar alpha-amino side groups but also similar main chain to epsilon-pl were chemically synthesized for the first time though click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. with microwave-assisting, the reaction time of click polymerization was compressed into 30 min. the polymers were fully characterized by nmr, atr-ftir, and sec-malls analysis. the deprotected click polypeptides had similar pk(a) value (7.5) and relatively low cytotoxicity as epsilon-pl and could be used as substitutes of epsilon-pl in biomedical applications, especially in endotoxin selective removal. poly(ethylene glycol) (peg)-containing alternating copolymers with a-amino groups were also synthesized and characterized. after deprotection, the polymers could be used as functional gene vector with peg shadowing system and nca initiator to get amphiphilic graft polymers. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000288183100027 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44786]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guo JS,Wei Y,Zhou DF,et al. Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization[J]. biomacromolecules,2011,12(3):737-746. |
| APA | Guo JS.,Wei Y.,Zhou DF.,Cai PQ.,Jing XB.,...&Huang YB.(2011).Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization.biomacromolecules,12(3),737-746. |
| MLA | Guo JS,et al."Chemosynthesis of Poly(epsilon-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization".biomacromolecules 12.3(2011):737-746. |
入库方式： OAI收割
来源：长春应用化学研究所
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