Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection
文献类型：期刊论文
| 作者 | Yu CX ; Du HW ; You TY |
| 刊名 | talanta
 |
| 出版日期 | 2011 |
| 卷号 | 83期号:5页码:1376-1380 |
| 关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY SUBSTITUTED AROMATIC-ACIDS CARBON-PASTE ELECTRODE AQUEOUS-ORGANIC MEDIA TRICYCLIC ANTIDEPRESSANTS ZONE-ELECTROPHORESIS IONIC MOBILITIES MASS-SPECTROMETRY BETA-CYCLODEXTRIN HUMAN PLASMA |
| ISSN号 | 0039-9140 |
| 通讯作者 | you ty |
| 中文摘要 | the tricyclic antidepressants (tca) imipramine (imi) and trimipramine (tri) were successfully analyzed by capillary electrophoresis (ce) coupling with tris(2,2-bipyridyl) ruthenium(ii)-based (ru(bpy)(3)(2+)) end-column electrochemiluminescence (ecl) detection. the addition of beta-cd to the running buffer was found to enable baseline separation of the two analytes and the addition of acetonitrile (acn) as an organic additive to improve the repeatability and sensitivity of the ce method. under the optimized separation and detection conditions (50 mm pbs (ph = 7.0) and 2 mm ru(bpy)(3)(2+) in the ecl detection cell. 20 mm tris (ph = 2.0). 0.2 mm beta-cd and 20% acn (v/v) as running buffer), wide linear ranges of 0.1-5 mu m and 0.1-5 mu m were achieved, with the correlation coefficients of 0.9990 (n = 8) and 0.9980 (n = 8) for imi and tri, respectively. detection limits 5 nm and 1 nm (s/n = 3) were obtained for imi and tri, respectively. the method was also successfully applied for the determination of imi in pharmaceutical dosage form. (c) 2010 elsevier b.v. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287110100010 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44810]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu CX,Du HW,You TY. Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection[J]. talanta,2011,83(5):1376-1380. |
| APA | Yu CX,Du HW,&You TY.(2011).Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection.talanta,83(5),1376-1380. |
| MLA | Yu CX,et al."Determination of imipramine and trimipramine by capillary electrophoresis with electrochemiluminescence detection".talanta 83.5(2011):1376-1380. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。