Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection
文献类型：期刊论文
| 作者 | Xia JL ; Chen L ; Chen J ; Tian HY ; Li FF ; Zhu XJ ; Li G ; Chen XS |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:2页码:211-218 |
| 关键词 | ADENOASSOCIATED VIRUS GLYCOL) COPOLYMERS BUFFERING CAPACITY DELIVERY VECTORS NANOPARTICLES THERAPY CARRIERS EXPRESSION RESIDUES POLYMERS |
| ISSN号 | 1616-5187 |
| 通讯作者 | chen xs |
| 中文摘要 | a series of amphiphilic multi-armed ppn copolymers were prepared by rop of phe-nca with pei-25k as a macroinitiator. the particle size of the ppn/dna complexes was about 100 nm and the zeta potentials were below 20 mv. an mtt assay demonstrated that all the ppn copolymers had lower cytotoxicity compared to pei-25k. in vitro gene transfection studies were also conducted in hela, 293 and ct 26 cells. the optimal quantity of hydrophobic phenylalanine segments in pp80 led to higher transfection efficiency in various cell lines based on this study. the results indicate that pp80 was the best candidate for gene delivery among these ppn copolymers. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287162800006 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44822]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xia JL,Chen L,Chen J,et al. Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection[J]. macromolecular bioscience,2011,11(2):211-218. |
| APA | Xia JL.,Chen L.,Chen J.,Tian HY.,Li FF.,...&Chen XS.(2011).Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection.macromolecular bioscience,11(2),211-218. |
| MLA | Xia JL,et al."Hydrophobic Polyphenylalanine-Grafted Hyperbranched Polyethylenimine and its in vitro Gene Transfection".macromolecular bioscience 11.2(2011):211-218. |
入库方式： OAI收割
来源：长春应用化学研究所
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