中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging

文献类型:期刊论文

作者Liu YL ; Ai KL ; Yuan QH ; Lu LH
刊名biomaterials
出版日期2011
卷号32期号:4页码:1185-1192
关键词MRI CONTRAST AGENTS SILICA NANOPARTICLES HIGH-RELAXIVITY RADIO-OPAQUE PHOTOLUMINESCENCE CELLS SEMICONDUCTOR DELIVERY SHELL PROBE
ISSN号0142-9612
通讯作者lu lh
中文摘要we report here the development of gd-doped zno quantum dots (qds) as dual modal fluorescence and magnetic resonance imaging nanoprobes. they are fabricated in a simple, versatile and environmentally friendly method, not only decreasing the difficulty and complexity, but also avoiding the increase of particle's size brought about by silica coating procedure in the synthesis of nanoprobes reported previously. these nanoprobes, with exceptionally small size and enhanced fluorescence resulting from the gd doping, can label successfully the hela cells in short time and present no evidence of toxicity or adverse affect on cell growth even at the concentration up to 1 mm. these results show that such nanoprobes have low toxicity, especially in comparison with the traditional pegylated cdse/zns or cdse/cds qds. in mri studies, they exert strong positive contrast effect with a large longitudinal relaxivity (r(1)) of water proton of 16 mm(-1) s(-1). their capability of imaging hela cells with mri implies that they have great potential as mri contrast agents. combining the high sensitivity of fluorescence imaging with high spatial resolution of mri, we expect that the as-prepared gd-doped zno qds can provide a better reliability of the collected data and find promising applications in biological, medical and other fields. (c) 2010 elsevier ltd. all rights reserved.
收录类别SCI收录期刊论文
语种英语
WOS记录号WOS:000285675200026
公开日期2012-06-11
源URL[http://ir.ciac.jl.cn/handle/322003/44861]  
专题长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式
GB/T 7714
Liu YL,Ai KL,Yuan QH,et al. Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging[J]. biomaterials,2011,32(4):1185-1192.
APA Liu YL,Ai KL,Yuan QH,&Lu LH.(2011).Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging.biomaterials,32(4),1185-1192.
MLA Liu YL,et al."Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging".biomaterials 32.4(2011):1185-1192.

入库方式: OAI收割

来源:长春应用化学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。