Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging
文献类型：期刊论文
| 作者 | Liu YL ; Ai KL ; Yuan QH ; Lu LH |
| 刊名 | biomaterials
 |
| 出版日期 | 2011 |
| 卷号 | 32期号:4页码:1185-1192 |
| 关键词 | MRI CONTRAST AGENTS SILICA NANOPARTICLES HIGH-RELAXIVITY RADIO-OPAQUE PHOTOLUMINESCENCE CELLS SEMICONDUCTOR DELIVERY SHELL PROBE |
| ISSN号 | 0142-9612 |
| 通讯作者 | lu lh |
| 中文摘要 | we report here the development of gd-doped zno quantum dots (qds) as dual modal fluorescence and magnetic resonance imaging nanoprobes. they are fabricated in a simple, versatile and environmentally friendly method, not only decreasing the difficulty and complexity, but also avoiding the increase of particle's size brought about by silica coating procedure in the synthesis of nanoprobes reported previously. these nanoprobes, with exceptionally small size and enhanced fluorescence resulting from the gd doping, can label successfully the hela cells in short time and present no evidence of toxicity or adverse affect on cell growth even at the concentration up to 1 mm. these results show that such nanoprobes have low toxicity, especially in comparison with the traditional pegylated cdse/zns or cdse/cds qds. in mri studies, they exert strong positive contrast effect with a large longitudinal relaxivity (r(1)) of water proton of 16 mm(-1) s(-1). their capability of imaging hela cells with mri implies that they have great potential as mri contrast agents. combining the high sensitivity of fluorescence imaging with high spatial resolution of mri, we expect that the as-prepared gd-doped zno qds can provide a better reliability of the collected data and find promising applications in biological, medical and other fields. (c) 2010 elsevier ltd. all rights reserved. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000285675200026 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44861]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu YL,Ai KL,Yuan QH,et al. Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging[J]. biomaterials,2011,32(4):1185-1192. |
| APA | Liu YL,Ai KL,Yuan QH,&Lu LH.(2011).Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging.biomaterials,32(4),1185-1192. |
| MLA | Liu YL,et al."Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging".biomaterials 32.4(2011):1185-1192. |
入库方式： OAI收割
来源：长春应用化学研究所
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