Small Interfering RNA for Effective Cancer Therapies
文献类型：期刊论文
| 作者 | Wang X ; Chen Y ; Ren J ; Qu X |
| 刊名 | mini-reviews in medicinal chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:2页码:114-124 |
| 关键词 | HUMAN BREAST-CANCER TELOMERASE REVERSE-TRANSCRIPTASE NASOPHARYNGEAL CARCINOMA-CELLS HUMAN HEPATOCELLULAR-CARCINOMA ABL GENE-EXPRESSION IN-VIVO DELIVERY POLO-LIKE KINASE WILD-TYPE P53 DOWN-REGULATION COLORECTAL-CARCINOMA |
| ISSN号 | 1389-5575 |
| 通讯作者 | qu x |
| 中文摘要 | small interfering rna (sirna) has become a specific and powerful tool to turn off the expression of target genes, and has turned into a promising tool in molecular medicine. it can be targeted against cancer by several strategies. these include the suppression of overexpressed oncogenes, retarding cell division by interfering with cyclins and related genes or enhancing apoptosis by inhibiting anti-apoptotic genes. rna interference (rnai) against multidrug resistance (mdr) genes or chemo/radio-resistance and angiogenesis targets may also provide beneficial cancer treatments. successful cancer therapy by sirna in vitro and in vivo provides the enthusiasm for potential therapeutic applications of this technique. here, we review rnai in cancer therapy, highlighting recent progress and examining the hurdles that must be overcome before this promising technology is ready for clinical use. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287356300002 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44863]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang X,Chen Y,Ren J,et al. Small Interfering RNA for Effective Cancer Therapies[J]. mini-reviews in medicinal chemistry,2011,11(2):114-124. |
| APA | Wang X,Chen Y,Ren J,&Qu X.(2011).Small Interfering RNA for Effective Cancer Therapies.mini-reviews in medicinal chemistry,11(2),114-124. |
| MLA | Wang X,et al."Small Interfering RNA for Effective Cancer Therapies".mini-reviews in medicinal chemistry 11.2(2011):114-124. |
入库方式： OAI收割
来源：长春应用化学研究所
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