Rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsules as carriers for drug delivery
文献类型：期刊论文
| 作者 | Zhai XF ; Yu M ; Cheng ZY ; Hou ZY ; Ma PA ; Yang DM ; Kang XJ ; Dai YL ; Wang D ; Lin J |
| 刊名 | dalton transactions
 |
| 出版日期 | 2011 |
| 卷号 | 40期号:48页码:12818-12825 |
| 关键词 | CORE-SHELL MESOPOROUS SPHERES SILICA SPHERES GOLD NANOPARTICLES SPHERICAL COLLOIDS CARBON SPHERES PARTICLES ROUTE ENCAPSULATION NANOREACTORS |
| ISSN号 | 1477-9226 |
| 通讯作者 | cheng zy |
| 中文摘要 | rattle-type hollow nanocapsules are among of the most promising candidates as drug carriers owing to their huge inner space and multifunctional material combination. in this paper, rattle-type hollow cawo(4):tb(3+)@sio(2) nanocapsules with a diameter of 100-110 nm and a wall thickness around 10 nm were fabricated. the hollow silica nanospheres were used as nano-reactors and the luminescent core of cawo(4):tb(3+) was post-filled into the nano-reactors by a vacuum nano-casting route combined with a pechini-type sol-gel method. subsequently, doxorubicin hydrochloride (dox), a model of an anti-cancer drug, is loaded into the cawo(4):tb(3+)@sio(2) nanocapsules and their cell cytotoxicity, cancer cell uptake and drug release behavior are investigated in vitro. the prepared multifunctional inorganic nanocapsules show a loading capacity for dox as high as 124 mg g(-1) and sustained-release properties. the release profile of the drug from dox-loaded nanocapsules can last over five days. besides, the blank cawo(4):tb(3+)@sio(2) shows very low cytotoxicity against cancer cell lines (hela cell) while the dox-loaded nanocapsules exhibit relatively high efficiency for killing of hela cells. the rapid cancer cell uptake process is observed by confocal laser scanning microscopy. the results indicate that a rattle-type hollow cawo(4):tb(3+)@sio(2) nanocapsule has the potential to be used as drug carrier in therapy. moreover, it is possible to extend the synthetic strategy in this study to other rattle-type multifunctional composites to meet various demands. |
| 语种 | 英语 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44895]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhai XF,Yu M,Cheng ZY,et al. Rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsules as carriers for drug delivery[J]. dalton transactions,2011,40(48):12818-12825. |
| APA | Zhai XF.,Yu M.,Cheng ZY.,Hou ZY.,Ma PA.,...&Lin J.(2011).Rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsules as carriers for drug delivery.dalton transactions,40(48),12818-12825. |
| MLA | Zhai XF,et al."Rattle-type hollow CaWO(4):Tb(3+)@SiO(2) nanocapsules as carriers for drug delivery".dalton transactions 40.48(2011):12818-12825. |
入库方式： OAI收割
来源：长春应用化学研究所
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