One-step preparation of reduction-responsive poly(ethylene glycol)-poly (amino acid)s nanogels as efficient intracellular drug delivery platforms
文献类型：期刊论文
| 作者 | Ding JX ; Shi FH ; Xiao CS ; Lin L ; Chen L ; He CL ; Zhuang XL ; Chen XS |
| 刊名 | polymer chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 2期号:12页码:2857-2864 |
| 关键词 | TRANSFER RADICAL POLYMERIZATION POLYPEPTIDE BACKBONE COPOLYMER MICELLES BLOCK-COPOLYMER NANOPARTICLES DOXORUBICIN POLYMERS VESICLES CARRIERS RELEASE |
| ISSN号 | 1759-9954 |
| 通讯作者 | chen l |
| 中文摘要 | a series of disulfide-core-cross-linked poly(ethylene glycol)-poly(amino acid)s star copolymers were synthesized through one-step ring-opening polymerization of l-phenylalanine n-carboxyanhydride (l-phe nca) and l-cystine n-carboxyanhydride (l-cys nca) with amino group terminated poly (ethylene glycol) monomethyl ether (mpeg-nh(2)) as macroinitiator. the reduction-responsive peg-poly(amino acid) s nanogels (ngs) were prepared by directly dispersing the resultant peg-poly(amino acid) s in phosphate buffer solution at ph 7.4. dynamic light scattering (dls) measurements showed that the reducible ng swelled in response to 10 mm glutathione (gsh). doxorubicin (dox), an anthracycline anticancer drug, was loaded into the ngs. the in vitro release results revealed that the release behaviors could be adjusted by gsh concentration, and poly(amino acid) s content and composition. the intracellular dox release results showed that enhanced intracellular dox release occurred in gsh pretreated henrietta lacks (hela) cells. in vitro methyl thiazolyl tetrazolium (mtt) assays indicated that the ngs were biocompatible, and dox-loaded ng showed higher cellular proliferation inhibition towards gsh pretreated hela cells than that of non-pretreated cells. therefore, the ngs can efficiently deliver anticancer drugs into tumor cells and inhibit cell proliferation, rendering highly promising for targeted intracellular delivery of operative chemotherapeutic drugs in cancer therapy. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000296743500022 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44910]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ding JX,Shi FH,Xiao CS,et al. One-step preparation of reduction-responsive poly(ethylene glycol)-poly (amino acid)s nanogels as efficient intracellular drug delivery platforms[J]. polymer chemistry,2011,2(12):2857-2864. |
| APA | Ding JX.,Shi FH.,Xiao CS.,Lin L.,Chen L.,...&Chen XS.(2011).One-step preparation of reduction-responsive poly(ethylene glycol)-poly (amino acid)s nanogels as efficient intracellular drug delivery platforms.polymer chemistry,2(12),2857-2864. |
| MLA | Ding JX,et al."One-step preparation of reduction-responsive poly(ethylene glycol)-poly (amino acid)s nanogels as efficient intracellular drug delivery platforms".polymer chemistry 2.12(2011):2857-2864. |
入库方式： OAI收割
来源：长春应用化学研究所
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