Fibrous-structured magnetic and mesoporous Fe(3)O(4)/silica microspheres: synthesis and intracellular doxorubicin delivery
文献类型：期刊论文
| 作者 | Gai SL ; Yang PP ; Ma PA ; Wang D ; Li CX ; Li XB ; Niu N ; Lin J |
| 刊名 | journal of materials chemistry
 |
| 出版日期 | 2011 |
| 卷号 | 21期号:41页码:16420-16426 |
| 关键词 | IRON-OXIDE NANOPARTICLES SOL-GEL PROCESS CONTROLLED-RELEASE HOLLOW SPHERES SILICA SPHERES DRUG-DELIVERY PHOTODYNAMIC THERAPY GENERAL-APPROACH NANOCRYSTALS SYSTEM |
| ISSN号 | 0959-9428 |
| 通讯作者 | yang pp |
| 中文摘要 | a novel, fibrous-structured bifunctional (magnetic and mesoporous) fe(3)o(4)/silica microsphere was successfully synthesized through a simple and economical self-assembled process in which hydrophobic 9 nm-fe(3)o(4) nanocrystals were directly used without modifications. the obtained material is performed as a drug delivery carrier to investigate the in vitro and intracellular delivery properties of doxorubicin hydrochloride (dox). x-ray diffraction (xrd), scanning electron microscopy (sem), transmission electron microscopy (tem), n(2) adsorption/desorption, fourier transform infrared spectroscopy (ftir), and superconducting quantum interference device (squid) were employed to characterize the composite. the results reveal that the novel composite exhibits typical mesoporous structure, narrow size distribution, good monodispersity, and superparamagnetic features. notably, confocal laser scanning microscopy (clsm) images indicate that the dox-loaded sample could deliver dox into the nuclei of hela cells to kill cells. also, mtt assay confirms that the dox-loaded sample leads to pronounced and efficient cytotoxic effects to l929 fibroblast cells, even similar to that of free dox at high concentrations, whereas the pure material is non-toxic. therefore, the novel material is expected to have potential application for targeted cancer therapy. |
| 语种 | 英语 |
| 公开日期 | 2012-06-11 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/44931]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Gai SL,Yang PP,Ma PA,et al. Fibrous-structured magnetic and mesoporous Fe(3)O(4)/silica microspheres: synthesis and intracellular doxorubicin delivery[J]. journal of materials chemistry,2011,21(41):16420-16426. |
| APA | Gai SL.,Yang PP.,Ma PA.,Wang D.,Li CX.,...&Lin J.(2011).Fibrous-structured magnetic and mesoporous Fe(3)O(4)/silica microspheres: synthesis and intracellular doxorubicin delivery.journal of materials chemistry,21(41),16420-16426. |
| MLA | Gai SL,et al."Fibrous-structured magnetic and mesoporous Fe(3)O(4)/silica microspheres: synthesis and intracellular doxorubicin delivery".journal of materials chemistry 21.41(2011):16420-16426. |
入库方式： OAI收割
来源：长春应用化学研究所
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