Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example
文献类型：期刊论文
| 作者 | Jiang, Huifeng1,2; Guo, Xiaoxian1,3; Xu, Lin1,4; Gu, Zhenglong1 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2012-09-01 |
| 卷号 | 29期号:9页码:2169-2176 |
| 关键词 | posttranscriptional regulon evolution of gene regulation yeast |
| 英文摘要 | It has been increasingly clear that changes in gene regulation play important roles in physiological and phenotypic evolution. Rewiring gene-regulatory networks, i.e., alteration of the gene-regulation system for different biological functions, has been demonstrated in various species. Posttranscriptional regulons have prominent roles in coordinating gene expression in a variety of eukaryotes. In this study, using Puf4p in fungi as an example, we demonstrate that posttranscriptional regulatory networks can also be rewired during evolution. Although Puf4p is highly conserved in fungi, targets of the posttranscriptional regulon are functionally diverse among known fungal species. In the Saccharomycotina subdivision, target genes of Puf4p mostly conduct function in the nucleolus; however, in the Pezizomycotina subdivision, they are enriched in the mitochondria. Furthermore, we demonstrate different regulation efficiencies of mitochondrial function by PUF proteins in different fungal clades. Our results indicate that rewiring of posttranscription regulatory networks may be an important way of generating genetic novelties in gene regulation during evolution. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 关键词[WOS] | MULTIPLE SEQUENCE ALIGNMENT ; GERMLINE STEM-CELLS ; MESSENGER-RNA ; BINDING PROTEINS ; GIARDIA-LAMBLIA ; GENE-EXPRESSION ; EVOLUTION ; YEAST ; DROSOPHILA ; GENOME |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000308851600010 |
| 公开日期 | 2012-05-31 |
| 源URL | [http://localhost/handle/0/240]  |
| 专题 | 天津工业生物技术研究所_酵母基因组工程课题组 江会锋_期刊论文 |
| 作者单位 | 1.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA 2.Chinese Acad Sci, Inst Tianjin Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin, Peoples R China 3.Zhejiang Univ, Coll Life Sci, Hangzhou 310003, Zhejiang, Peoples R China 4.Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA |
| 推荐引用方式 GB/T 7714 | Jiang, Huifeng,Guo, Xiaoxian,Xu, Lin,et al. Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(9):2169-2176. |
| APA | Jiang, Huifeng,Guo, Xiaoxian,Xu, Lin,&Gu, Zhenglong.(2012).Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example.MOLECULAR BIOLOGY AND EVOLUTION,29(9),2169-2176. |
| MLA | Jiang, Huifeng,et al."Rewiring of Posttranscriptional RNA Regulons: Puf4p in Fungi as an Example".MOLECULAR BIOLOGY AND EVOLUTION 29.9(2012):2169-2176. |
入库方式： OAI收割
来源：天津工业生物技术研究所
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