Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts
文献类型：期刊论文
| 作者 | Lee, Yun Mi1; Kim, Young Sook1; Lee, Youngseop1; Kim, Junghyun1; Sun, Hang2 ; Kim, Joo Hwan3; Kim, Jin Sook1
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| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2012-05-01 |
| 卷号 | 26期号:5页码:778-782 |
| 关键词 | pancreatic lipase phosphodiesterase Korean medicinal plants Sorbus commixta Viscum album |
| ISSN号 | 0951-418X |
| 通讯作者 | Kim, JS (reprint author), KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, 483 Exporo, Taejon 305811, South Korea, jskim@kiom.re.kr |
| 英文摘要 | To find new pancreatic lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) inhibitors from natural products, 61 medicinal plants from Korea were screened for their antilipase activity for prevention of obesity. Dried and powdered plants were extracted three times with EtOH and extracts were obtained by removal of the solvent in vacuo. Lipase activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol. Also, the inhibitory effect was measured on phosphodiesterase (PDE), another therapeutic target for obesity. Of the extracts tested, Sorbus commixta (stem, leaf) and Viscum album (whole plant) exhibited antilipase activity (with IC50 values of 29.6?mu g/mL and 33.3?mu g/mL, respectively) and only anti-PDE activity (IC50 values of 20.08?mu g/mL and 35.15?mu g/mL, respectively). Copyright (c) 2011 John Wiley & Sons, Ltd. |
| 学科主题 | Chemistry, Medicinal; Pharmacology & Pharmacy |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | SORBUS-COMMIXTA ; OBESITY |
| 收录类别 | SCI |
| 资助信息 | Korea Research Council of Fundamental Science and Technology (KRCF)[G10100]; Korea Institute of Oriental Medicine (KIOM)[K10040] |
| 语种 | 英语 |
| WOS记录号 | WOS:000302936700023 |
| 公开日期 | 2012-06-07 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/10475]  |
| 专题 | 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 作者单位 | 1.KIOM, Diabet Complicat Res Ctr, Div Tradit Korean Med TKM Integrated Res, Taejon 305811, South Korea 2.Chinese Acad Sci, Lab Biodivers & Biogeog, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 3.Kyungwon Univ, Dept Life Sci, Songnam 461701, Kyonggi Do, South Korea |
| 推荐引用方式 GB/T 7714 | Lee, Yun Mi,Kim, Young Sook,Lee, Youngseop,et al. Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts[J]. PHYTOTHERAPY RESEARCH,2012,26(5):778-782. |
| APA | Lee, Yun Mi.,Kim, Young Sook.,Lee, Youngseop.,Kim, Junghyun.,Sun, Hang.,...&Kim, Jin Sook.(2012).Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts.PHYTOTHERAPY RESEARCH,26(5),778-782. |
| MLA | Lee, Yun Mi,et al."Inhibitory Activities of Pancreatic Lipase and Phosphodiesterase from Korean Medicinal Plant Extracts".PHYTOTHERAPY RESEARCH 26.5(2012):778-782. |
入库方式： OAI收割
来源：昆明植物研究所
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