SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
文献类型：期刊论文
| 作者 | Guo, Zhenhua2 ; Adomas, Aleksandra B.1; Jackson, Erin D.3; Qin, Hong3; Townsend, Jeffrey P.1
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| 刊名 | FEMS YEAST RESEARCH
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| 出版日期 | 2011-06-01 |
| 卷号 | 11期号:4页码:345-355 |
| 关键词 | transcriptomics longevity gene expression microarray life span variation |
| 英文摘要 | We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention. |
| 学科主题 | Biotechnology & Applied Microbiology; Microbiology; Mycology |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Microbiology ; Mycology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Microbiology ; Mycology |
| 关键词[WOS] | LIFE-SPAN EXTENSION ; GRANGER CAUSALITY ; CALORIE RESTRICTION ; MODEL ORGANISMS ; DNA-DAMAGE ; C-ELEGANS ; LONGEVITY ; MITOCHONDRIA ; SENESCENCE ; GENOME |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000290408800004 |
| 公开日期 | 2012-06-12 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/11219]  |
| 专题 | 昆明植物研究所_中国西南野生生物种质资源库 |
| 作者单位 | 1.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA 2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Beijing 100864, Peoples R China 3.Spelman Coll, Dept Biol, Atlanta, GA 30314 USA |
| 推荐引用方式 GB/T 7714 | Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,et al. SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae[J]. FEMS YEAST RESEARCH,2011,11(4):345-355. |
| APA | Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,Qin, Hong,&Townsend, Jeffrey P..(2011).SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.FEMS YEAST RESEARCH,11(4),345-355. |
| MLA | Guo, Zhenhua,et al."SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae".FEMS YEAST RESEARCH 11.4(2011):345-355. |
入库方式： OAI收割
来源：昆明植物研究所
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