A luminescent and mesoporous core-shell structured Gd(2)O(3):Eu(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier
文献类型：期刊论文
| 作者 | Xu ZH ; Gao Y ; Huang SS ; Ma PA ; Lin J ; Fang JY |
| 刊名 | dalton transactions
 |
| 出版日期 | 2011 |
| 卷号 | 40期号:18页码:4846-4854 |
| 关键词 | UP-CONVERSION GD2O3 NANOCRYSTALS CONTROLLED-RELEASE SILICA NANOSPHERE LIGHT EMISSION IN-VITRO DELIVERY HYDROXYAPATITE NANOPARTICLES SPECTROSCOPY |
| ISSN号 | 1477-9226 |
| 通讯作者 | lin j |
| 中文摘要 | in this paper, gd(2)o(3):eu(3+) nanospheres have been encapsulated with nonporous silica and further layer of ordered mesoporous silica through a simple sol-gel process. x-ray diffraction (xrd), scanning electron microscopy (sem), transmission electron microscopy (tem), n(2) adsorption/desorption, photoluminescence (pl) spectra, and kinetic decay were used to characterize the sample. the results indicate that the nanocomposite with general 50 nm shell thickness and 270 nm core size shows typical ordered mesoporous characteristics (2.4 nm) and has spherical morphology with a smooth surface and narrow size distribution. additionally, the obtained inorganic nanocomposite shows the characteristic emission of eu(3+) ((5)d(0)->(7)f(1-4)) even after the loading of drug molecules. the biocompatibility test on l929 fibroblast cells using mtt assay reveals low cytotoxicity of the system. most importantly, the nanocomposite can be used as an effective drug delivery carrier. a typical anticancer drug, doxorubicin hydrochloride (dox), was used for drug loading, and the dox release, cytotoxicity, uptake behavior and therapeutic effects were examined. it was found that dox is shuttled into the cell by the nanocomposite and released inside cells after endocytosis and that the dox-loaded nanocomposite exhibited greater cytotoxicity than free dox. these results indicate that core-shell structured gd(2)o(3):eu(3+)@nsio(2)@msio(2) nanocomposite has potential for drug loading and delivery into cancer cells to induce cell death. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| 公开日期 | 2012-06-12 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/45009]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu ZH,Gao Y,Huang SS,et al. A luminescent and mesoporous core-shell structured Gd(2)O(3):Eu(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier[J]. dalton transactions,2011,40(18):4846-4854. |
| APA | Xu ZH,Gao Y,Huang SS,Ma PA,Lin J,&Fang JY.(2011).A luminescent and mesoporous core-shell structured Gd(2)O(3):Eu(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier.dalton transactions,40(18),4846-4854. |
| MLA | Xu ZH,et al."A luminescent and mesoporous core-shell structured Gd(2)O(3):Eu(3+)@nSiO(2)@mSiO(2) nanocomposite as a drug carrier".dalton transactions 40.18(2011):4846-4854. |
入库方式： OAI收割
来源：长春应用化学研究所
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